A Positron-probe System for Arterial Input Function Quantification for Positron Emission Tomography in Humans

Overview

Journal Rev Sci Instrum

Publisher American Institute of Physics

Specialties Biomedical Engineering
Biophysics

Date 2008 Jul 8

PMID 18601420

Citations 2

Authors

Kihak Lee

Peter T Fox

Jack L Lancaster

Paul A Jerabek

Affiliations

Soon will be listed here.

Abstract

We developed an intra-arterial positron-probe (beta(+)-probe) system to measure the arterial time-activity concentration in humans for quantitative compartmental modeling of positron emission tomography studies. Performance was characterized in vitro, by using a uniform phantom to calculate dead time, linearity, and absolute detector sensitivity. In vitro evaluations in a uniform phantom showed a system dead time of 2.5 micros, linear regression between measured and true count rates with R(2)=0.999, and detector sensitivity of 6.9-7.0 counts/s kBq(-1) ml. These met or exceeded values of previously reported systems.

Citing Articles

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References

Zimmer L, Pain F, Mauger G, Plenevaux A, LE Bars D, Mastrippolito R . The potential of the beta-Microprobe, an intracerebral radiosensitive probe, to monitor the [(18)F]MPPF binding in the rat dorsal raphe nucleus. Eur J Nucl Med Mol Imaging. 2002; 29(9):1237-47. DOI: 10.1007/s00259-002-0866-6. View

Votaw J, Shulman S . Performance evaluation of the Pico-Count flow-through detector for use in cerebral blood flow PET studies. J Nucl Med. 1998; 39(3):509-15. View

Raichle M, Martin W, Herscovitch P, Mintun M, Markham J . Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation. J Nucl Med. 1983; 24(9):790-8. View

Seki C, Okada H, Mori S, Kakiuchi T, Yoshikawa E, Nishiyama S . Application of a beta microprobe for quantification of regional cerebral blood flow with (15)O-water and PET in rhesus monkeys. Ann Nucl Med. 1998; 12(1):7-14. DOI: 10.1007/BF03165410. View

Mintun M, Raichle M, Martin W, Herscovitch P . Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography. J Nucl Med. 1984; 25(2):177-87. View

Maguire R, Spyrou N, Leenders K . Whole body [O-15]water pharmacokinetics measured in blood. Physiol Meas. 2003; 24(2):237-49. DOI: 10.1088/0967-3334/24/2/301. View

Pain F, Laniece P, Mastrippolito R, Gervais P, Hantraye P, Besret L . Arterial input function measurement without blood sampling using a beta-microprobe in rats. J Nucl Med. 2004; 45(9):1577-82. View

Hattori N, Bergsneider M, Wu H, Glenn T, Vespa P, Hovda D . Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans. J Nucl Med. 2004; 45(5):765-70. View

Yee S, Jerabek P, Fox P . Non-invasive quantification of cerebral blood flow for rats by microPET imaging of 15O labelled water: the application of a cardiac time-activity curve for the tracer arterial input function. Nucl Med Commun. 2005; 26(10):903-11. DOI: 10.1097/00006231-200510000-00009. View

10.

Champion C, Loirec C . Positron follow-up in liquid water: II. Spatial and energetic study for the most important radioisotopes used in PET. Phys Med Biol. 2007; 52(22):6605-25. DOI: 10.1088/0031-9155/52/22/004. View

11.

Eriksson L, Kanno I . Blood sampling devices and measurements. Med Prog Technol. 1991; 17(3-4):249-57. View

12.

Watabe H, Itoh M, Mejia M, Fujiwara T, Jones T, Nakamura T . Validation of noninvasive quantification of rCBF compared with dynamic/integral method by using positron emission tomography and oxygen-15 labeled water. Ann Nucl Med. 1995; 9(4):191-8. DOI: 10.1007/BF03168400. View

13.

Herscovitch P, Markham J, Raichle M . Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis. J Nucl Med. 1983; 24(9):782-9. View

14.

Ohta S, Meyer E, Fujita H, Reutens D, Evans A, Gjedde A . Cerebral [15O]water clearance in humans determined by PET: I. Theory and normal values. J Cereb Blood Flow Metab. 1996; 16(5):765-80. DOI: 10.1097/00004647-199609000-00002. View

15.

Watabe H, Itoh M, Cunningham V, Lammertsma A, Bloomfield P, Mejia M . Noninvasive quantification of rCBF using positron emission tomography. J Cereb Blood Flow Metab. 1996; 16(2):311-9. DOI: 10.1097/00004647-199603000-00017. View

16.

Fox P, Raichle M . Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci U S A. 1986; 83(4):1140-4. PMC: 323027. DOI: 10.1073/pnas.83.4.1140. View

17.

Ohta S, Meyer E, Thompson C, Gjedde A . Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. J Cereb Blood Flow Metab. 1992; 12(2):179-92. DOI: 10.1038/jcbfm.1992.28. View

18.

Mejia M, Itoh M, Watabe H, Fujiwara T, Nakamura T . Simplified nonlinearity correction of oxygen-15-water regional cerebral blood flow images without blood sampling. J Nucl Med. 1994; 35(11):1870-7. View

19.

Watabe H, Ikoma Y, Kimura Y, Naganawa M, Shidahara M . PET kinetic analysis--compartmental model. Ann Nucl Med. 2007; 20(9):583-8. DOI: 10.1007/BF02984655. View

20.

Fox P, Raichle M . Stimulus rate dependence of regional cerebral blood flow in human striate cortex, demonstrated by positron emission tomography. J Neurophysiol. 1984; 51(5):1109-20. DOI: 10.1152/jn.1984.51.5.1109. View