Beneficial Effects of Intranasal Applications of Capsaicin in Patients with Vasomotor Rhinitis

Overview

Journal Eur Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 1991 Jan 1

PMID 1859650

Citations 11

Authors

S Marabini

P G Ciabatti

G Polli

B M Fusco

P Geppetti

Affiliations

Soon will be listed here.

Abstract

Capsaicin, a nonenamide derived from Capsicum plants, has proven useful in patients with vasomotor rhinitis. In the present study, we studied the effects of 15 micrograms capsaicin suspended in 100 microliters solution in patients with known vasomotor rhinitis. Drug was given 3 times/day for 3 days to each patient by means of a spray delivered to the nasal mucosa. Acute effects induced by the drug included painful sensation and secretion of nasal fluid but were no longer observed at the last capsaicin application. Patients recorded their symptoms over a 1-month period. The mean symptom score involving nasal obstruction and nasal secretion was markedly reduced by capsaicin treatment. We advance the hypothesis that the beneficial effect of drug treatment may be due to its specific action on the peripheral endings of primary sensory neurons leading to their functional blockade. Further randomized, double-blind, placebo-controlled trial is now needed.

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References

Lundblad L, Lundberg J, Anggard A . Local and systemic capsaicin pretreatment inhibits sneezing and the increase in nasal vascular permeability induced by certain chemical irritants. Naunyn Schmiedebergs Arch Pharmacol. 1984; 326(3):254-61. DOI: 10.1007/BF00505327. View

Maggi C, Barbanti G, Santicioli P, Beneforti P, Misuri D, Meli A . Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans. J Urol. 1989; 142(1):150-4. DOI: 10.1016/s0022-5347(17)38701-3. View

MALCOMSON K . The vasomotor activities of the nasal mucous membrane. J Laryngol Otol. 1959; 73(2):73-98. DOI: 10.1017/s0022215100054980. View

GOLDING-WOOD P . Vidian neurectomy: its results and complications. Laryngoscope. 1973; 83(10):1673-83. DOI: 10.1288/00005537-197310000-00008. View

Konno A, TOGAWA K . Vidian neurectomy for allergic rhinitis. Evaluation of long-term results and some problems concerning operative therapy. Arch Otorhinolaryngol. 1979; 225(1):67-77. DOI: 10.1007/BF00455877. View

Geppetti P, Fusco B, Marabini S, Maggi C, Fanciullacci M, SICUTERI F . Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man. Br J Pharmacol. 1988; 93(3):509-14. PMC: 1853845. DOI: 10.1111/j.1476-5381.1988.tb10305.x. View

Holzer P . Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience. 1988; 24(3):739-68. DOI: 10.1016/0306-4522(88)90064-4. View

Maggi C, Meli A . The sensory-efferent function of capsaicin-sensitive sensory neurons. Gen Pharmacol. 1988; 19(1):1-43. DOI: 10.1016/0306-3623(88)90002-x. View

SICUTERI F, Fusco B, Marabini S, Campagnolo V, Maggi C, Geppetti P . Beneficial effect of capsaicin application to the nasal mucosa in cluster headache. Clin J Pain. 1989; 5(1):49-53. DOI: 10.1097/00002508-198903000-00010. View

10.

Lundblad L, Lundberg J, Brodin E, Anggard A . Origin and distribution of capsaicin-sensitive substance P-immunoreactive nerves in the nasal mucosa. Acta Otolaryngol. 1983; 96(5-6):485-93. DOI: 10.3109/00016488309132735. View

11.

Jones A, Lancer J . Vasomotor rhinitis. Br Med J (Clin Res Ed). 1987; 294(6586):1505-6. PMC: 1246666. DOI: 10.1136/bmj.294.6586.1505. View

12.

Watson P, Evans R, Watt V . Post-herpetic neuralgia and topical capsaicin. Pain. 1988; 33(3):333-340. DOI: 10.1016/0304-3959(88)90292-8. View

13.

Lundblad L . Protective reflexes and vascular effects in the nasal mucosa elicited by activation of capsaicin-sensitive substance P-immunoreactive trigeminal neurons. Acta Physiol Scand Suppl. 1984; 529:1-42. View

14.

Lundblad L, Saria A, Lundberg J, Anggard A . Increased vascular permeability in rat nasal mucosa induced by substance P and stimulation of capsaicin-sensitive trigeminal neurons. Acta Otolaryngol. 1983; 96(5-6):479-84. DOI: 10.3109/00016488309132734. View

15.

Watson C, Evans R, Watt V . The post-mastectomy pain syndrome and the effect of topical capsaicin. Pain. 1989; 38(2):177-86. DOI: 10.1016/0304-3959(89)90236-4. View

16.

Scott J, Huskisson E . Graphic representation of pain. Pain. 1976; 2(2):175-84. View

17.

Wolf G . [New aspects in the pathogenesis and therapy of hyperreflexive rhinopathy]. Laryngol Rhinol Otol (Stuttg). 1988; 67(9):438-45. View