Modulators of Transient Receptor Potential (TRP) Channels As Therapeutic Options in Lung Disease

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2019 Feb 6

PMID 30717260

Citations 32

Authors

Alexander Dietrich

Affiliations

Soon will be listed here.

Abstract

The lungs are essential for gas exchange and serve as the gateways of our body to the external environment. They are easily accessible for drugs from both sides, the airways and the vasculature. Recent literature provides evidence for a role of Transient Receptor Potential (TRP) channels as chemosensors and essential members of signal transduction cascades in stress-induced cellular responses. This review will focus on TRP channels (TRPA1, TRPC6, TRPV1, and TRPV4), predominantly expressed in non-neuronal lung tissues and their involvement in pathways associated with diseases like asthma, cystic fibrosis, chronic obstructive pulmonary disease (COPD), lung fibrosis, and edema formation. Recently identified specific modulators of these channels and their potential as new therapeutic options as well as strategies for a causal treatment based on the mechanistic understanding of molecular events will also be evaluated.

Citing Articles

TRPV4-A Multifunctional Cellular Sensor Protein with Therapeutic Potential.

Koskimaki S, Tojkander S Sensors (Basel). 2024; 24(21).

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TRPV4 Channel Modulators as Potential Drug Candidates for Cystic Fibrosis.

Orfali R, AlFaiz A, Alanazi M, Alabdulsalam R, Alharbi M, Alromaih Y Int J Mol Sci. 2024; 25(19).

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Luteolin Alleviates Oxidative Stress in Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke via Modulation of the TRPV1 and CYP2A13/NRF2 Signaling Pathways.

Zhou L, Jian T, Wan Y, Huang R, Fang H, Wang Y Int J Mol Sci. 2024; 25(1).

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Involvement of the Transient Receptor Channels in Preclinical Models of Musculoskeletal Pain.

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