Rogue Proliferation Versus Restorative Protection: Where Do We Draw the Line for Wnt and Forkhead Signaling?

Overview

Journal Expert Opin Ther Targets

Publisher Informa Healthcare

Specialty Pharmacology

Date 2008 Jun 17

PMID 18554157

Citations 30

Authors

Kenneth Maiese

Zhao Zhong Chong

Yan Chen Shang

Jinling Hou

Affiliations

Soon will be listed here.

Abstract

Background: Disease entities such as diabetes, neurodegeneration and cardiovascular disorders affect a significant portion of the world's population.

Objective: Given that cellular survival and longevity in multiple disorders are tied to oxidative stress, apoptotic cell injury and immune system deregulation, the development of robust therapeutic strategies rests heavily upon the ability to balance each of these parameters.

Methods: Here we discuss two exciting signaling pathways, namely Wnt and mammalian forkhead transcription factors predominantly of the O class superfamily, which can share integrated cytoprotective pathways during oxidative stress but may also adversely influence cellular survival and promote cancer cell proliferation.

Conclusion: Future investigations must elucidate the cellular determinants that govern the ability of Wnt and forkhead proteins to promote cellular longevity and possible disease remission but also allow for detrimental biological consequences and clinical compromise.

Citing Articles

Innovative therapeutic strategies for cardiovascular disease.

Maiese K EXCLI J. 2023; 22:690-715.

PMID: 37593239 PMC: 10427777. DOI: 10.17179/excli2023-6306.

Genome-Wide Association Analyses of Fertility Traits in Beef Heifers.

Stegemiller M, Murdoch G, Rowan T, Davenport K, Becker G, Hall J Genes (Basel). 2021; 12(2).

PMID: 33540904 PMC: 7913221. DOI: 10.3390/genes12020217.

Nicotinamide as a Foundation for Treating Neurodegenerative Disease and Metabolic Disorders.

Maiese K Curr Neurovasc Res. 2021; 18(1):134-149.

PMID: 33397266 PMC: 8254823. DOI: 10.2174/1567202617999210104220334.

Nicotinamide: Oversight of Metabolic Dysfunction Through SIRT1, mTOR, and Clock Genes.

Maiese K Curr Neurovasc Res. 2020; 17(5):765-783.

PMID: 33183203 PMC: 7914159. DOI: 10.2174/1567202617999201111195232.

Dysregulation of metabolic flexibility: The impact of mTOR on autophagy in neurodegenerative disease.

Maiese K Int Rev Neurobiol. 2020; 155:1-35.

PMID: 32854851 PMC: 7457955. DOI: 10.1016/bs.irn.2020.01.009.

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