MicroRNAs in Brain Function and Disease

Overview

Journal Curr Neurol Neurosci Rep

Specialty Neurology

Date 2008 Jun 11

PMID 18541114

Citations 34

Authors

Andreas Walter Kuss

Wei Chen

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs), a class of small, non-protein-coding transcripts about 21 nucleotides long, have recently entered center stage in the study of posttranscriptional gene regulation. They are now thought to be involved in the control of about one third of all protein-coding genes and play a role in the majority of cellular processes that have been studied. We focus on the role of the miRNA pathway in brain development, function, and disease by highlighting recent observations with respect to miRNA-mediated gene regulation in neuronal differentiation, synaptic plasticity, and the circadian clock. We also discuss the implications of these findings with respect to the involvement of miRNAs in the etiopathology of brain disorders and pinpoint the emerging therapeutic potential of miRNAs for the treatment of human diseases.

Citing Articles

MicroRNA-219 in the central nervous system: a potential theranostic approach.

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Deciphering the role of miRNA-134 in the pathophysiology of depression: A comprehensive review.

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Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease.

Riberas-Sanchez A, Puig-Parnau I, Vila-Soles L, Garcia-Brito S, Aldavert-Vera L, Segura-Torres P J Psychiatry Neurosci. 2024; 49(2):E96-E108.

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Sex-Biased Expression and Response of microRNAs in Neurological Diseases and Neurotrauma.

Geleta U, Prajapati P, Bachstetter A, Nelson P, Wang W Int J Mol Sci. 2024; 25(5).

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Therapeutic Implications of microRNAs in Depressive Disorders: A Review.

Hassan M, Amir A, Shahzadi S, Kloczkowski A Int J Mol Sci. 2022; 23(21).

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