Mannose-capped Lipoarabinomannan in Mycobacterium Tuberculosis Pathogenesis

Overview

Journal Pathog Dis

Publisher Oxford University Press

Specialties Infectious Diseases
Microbiology

Date 2018 May 4

PMID 29722821

Citations 50

Authors

Joanne Turner

Jordi B Torrelles

Affiliations

Soon will be listed here.

Abstract

Mannose-capped lipoarabinomannan (ManLAM), present in all members of the Mycobacterium tuberculosis complex and in other pathogenic Mycobacterium spp, is a high molecular mass amphipathic lipoglycan with a defined critical role in mycobacterial survival during infection. In particular, ManLAM is well-characterized for its importance in providing M. tuberculosis a safe portal of entry to phagocytes, regulating the intracellular trafficking network, as well as immune responses of infected host cells. These ManLAM immunological characteristics are thought to be linked to the subtle but unique and well-defined structural characteristics of this molecule, including but not limited to the degree of acylation, the length of the D-mannan and D-arabinan cores, the length of the mannose caps, as well as the presence of other acidic constituents such as succinates, lactates and/or malates, and also the presence of 5-methylthioxylosyl. The impact of all these structural features on ManLAM spatial conformation and biological functions during M. tuberculosis infection is still uncertain. In this review, we dissect the relationship between ManLAM structure and biological function addressing how this relationship determines M. tuberculosis interactions with host cells, and how it aids this exceptional pathogen during the course of infection.

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References

Glatman-Freedman A, Mednick A, Lendvai N, Casadevall A . Clearance and organ distribution of Mycobacterium tuberculosis lipoarabinomannan (LAM) in the presence and absence of LAM-binding immunoglobulin M. Infect Immun. 1999; 68(1):335-41. PMC: 97139. DOI: 10.1128/IAI.68.1.335-341.2000. View

Torrelles J, Schlesinger L . Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host. Tuberculosis (Edinb). 2010; 90(2):84-93. PMC: 2855779. DOI: 10.1016/j.tube.2010.02.003. View

Paris L, Magni R, Zaidi F, Araujo R, Saini N, Harpole M . Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity. Sci Transl Med. 2017; 9(420). PMC: 6037412. DOI: 10.1126/scitranslmed.aal2807. View

Busch M, Herzmann C, Kallert S, Zimmermann A, Hofer C, Mayer D . Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis. Am J Respir Crit Care Med. 2016; 194(3):345-55. PMC: 5441105. DOI: 10.1164/rccm.201509-1746OC. View

Tanne A, Ma B, Boudou F, Tailleux L, Botella H, Badell E . A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J Exp Med. 2009; 206(10):2205-20. PMC: 2757888. DOI: 10.1084/jem.20090188. View

Wieland C, Koppel E, Dunnen J, Florquin S, McKenzie A, van Kooyk Y . Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis. Microbes Infect. 2007; 9(2):134-41. DOI: 10.1016/j.micinf.2006.10.018. View

Nigou J, Gilleron M, Thurnher M, Puzo G . Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells: evidence for a negative signal delivered through the mannose receptor. J Immunol. 2001; 166(12):7477-85. DOI: 10.4049/jimmunol.166.12.7477. View

Rajaram M, Ni B, Morris J, Brooks M, Carlson T, Bakthavachalu B . Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. Proc Natl Acad Sci U S A. 2011; 108(42):17408-13. PMC: 3198317. DOI: 10.1073/pnas.1112660108. View

Villeneuve C, Gilleron M, Maridonneau-Parini I, Daffe M, Astarie-Dequeker C, Etienne G . Mycobacteria use their surface-exposed glycolipids to infect human macrophages through a receptor-dependent process. J Lipid Res. 2004; 46(3):475-83. DOI: 10.1194/jlr.M400308-JLR200. View

10.

Axelrod S, Oschkinat H, Enders J, Schlegel B, Brinkmann V, Kaufmann S . Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide. Cell Microbiol. 2008; 10(7):1530-45. DOI: 10.1111/j.1462-5822.2008.01147.x. View

11.

Shukla S, Richardson E, Athman J, Shi L, Wearsch P, McDonald D . Mycobacterium tuberculosis lipoprotein LprG binds lipoarabinomannan and determines its cell envelope localization to control phagolysosomal fusion. PLoS Pathog. 2014; 10(10):e1004471. PMC: 4214796. DOI: 10.1371/journal.ppat.1004471. View

12.

Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, Nota R . Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature. 2002; 420(6912):182-6. DOI: 10.1038/nature01195. View

13.

Quesniaux V, Nicolle D, Torres D, Kremer L, Guerardel Y, Nigou J . Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans. J Immunol. 2004; 172(7):4425-34. DOI: 10.4049/jimmunol.172.7.4425. View

14.

Geurtsen J, Chedammi S, Mesters J, Cot M, Driessen N, Sambou T . Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation. J Immunol. 2009; 183(8):5221-31. DOI: 10.4049/jimmunol.0900768. View

15.

Gaylord H, Brennan P . Leprosy and the leprosy bacillus: recent developments in characterization of antigens and immunology of the disease. Annu Rev Microbiol. 1987; 41:645-75. DOI: 10.1146/annurev.mi.41.100187.003241. View

16.

de la Salle H, Mariotti S, Angenieux C, Gilleron M, Garcia-Alles L, Malm D . Assistance of microbial glycolipid antigen processing by CD1e. Science. 2005; 310(5752):1321-4. DOI: 10.1126/science.1115301. View

17.

Athman J, Sande O, Groft S, Reba S, Nagy N, Wearsch P . Membrane Vesicles Inhibit T Cell Activation. J Immunol. 2017; 198(5):2028-2037. PMC: 5322216. DOI: 10.4049/jimmunol.1601199. View

18.

Velayati A, Farnia P, Ibrahim T, Haroun R, Kuan H, Ghanavi J . Differences in cell wall thickness between resistant and nonresistant strains of Mycobacterium tuberculosis: using transmission electron microscopy. Chemotherapy. 2009; 55(5):303-7. DOI: 10.1159/000226425. View

19.

McGreal E, Rosas M, Brown G, Zamze S, Wong S, Gordon S . The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology. 2006; 16(5):422-30. DOI: 10.1093/glycob/cwj077. View

20.

Stoop E, Mishra A, Driessen N, van Stempvoort G, Bouchier P, Verboom T . Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity. Cell Microbiol. 2013; 15(12):2093-108. PMC: 3963455. DOI: 10.1111/cmi.12175. View