Well-nourished Cystic Fibrosis Patients Have Normal Mineral Density, but Reduced Cortical Thickness at the Forearm

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2008 Jun 10

PMID 18536951

Citations 4

Authors

O Louis

P Clerinx

I Gies

E De Wachter

J De Schepper

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Our goal was to assess mineral density and geometry of the cortex at the level of the forearm in adolescents and young adults with cystic fibrosis, using peripheral quantitative computed tomography. We found that density was normal, but cortical thickness significantly reduced, as well in males as in females.

Introduction: Our goal was to measure bone mineral density as a volumetric density, as well as total cross-sectional area, cortical area and cortical thickness, using peripheral quantitative computed tomography (pQCT) at the forearm in adolescents and young adults with cystic fibrosis. We evaluated relationships between forearm bone measurements and body composition assessed using dual energy X-ray absorptiometry (DXA).

Methods: An XCT 2000 pQCT (Stratec, Pforzheim, Germany) and a QDR 4500 A-upgraded to Discovery DXA device (Hologic, Waltham, MA, USA) were used.

Results: Forty-eight patients (31 males,17 females, mean+/-SD 20+/5 years) were studied. Anthropometric features were: height 169+/- 10 cm, SDS 0.05+/-0.12, body mass index 19.8+/- 2.5 kg/m(2), SDS -0.56+/-0.14. Bone mineral density and total cross-sectional area of the forearm and body composition were normal, whereas cortical thickness was significantly reduced in males (mean Z-score - 1.22, p < 0.05), and in females (mean Z-score - 1.61, p < 0.05). Total body lean mass correlated more strongly with cortical thickness (r = 0.72, p < 0.001) than with total bone mineral density at the proximal radius (r = 0.39, p < 0.05).

Conclusions: Adolescents and young adults with cystic fibrosis, presenting with only a slight degree of underweight, have at the radius a preserved bone mineral density but a reduced cortical thickness.

Citing Articles

An update on methods for assessing bone quality and health in Cystic fibrosis.

Williams K, Darukhanavala A, Hicks R, Kelly A J Clin Transl Endocrinol. 2022; 27:100281.

PMID: 34984171 PMC: 8693345. DOI: 10.1016/j.jcte.2021.100281.

Peripheral quantitative computed tomography detects differences at the radius in prepubertal children with cystic fibrosis compared to healthy controls.

OBrien C, Com G, Fowlkes J, Tang X, James L PLoS One. 2018; 13(1):e0191013.

PMID: 29324908 PMC: 5764746. DOI: 10.1371/journal.pone.0191013.

Skeletal outcomes by peripheral quantitative computed tomography and dual-energy X-ray absorptiometry in adolescent girls with anorexia nervosa.

DiVasta A, Feldman H, ODonnell J, Long J, Leonard M, Gordon C Osteoporos Int. 2016; 27(12):3549-3558.

PMID: 27392467 PMC: 5881112. DOI: 10.1007/s00198-016-3685-5.

Compromised bone microarchitecture and estimated bone strength in young adults with cystic fibrosis.

Putman M, Milliren C, Derrico N, Uluer A, Sicilian L, Lapey A J Clin Endocrinol Metab. 2014; 99(9):3399-407.

PMID: 24926955 PMC: 4154107. DOI: 10.1210/jc.2014-1982.

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