Neurocalcin Delta Modulation of ROS-GC1, a New Model of Ca(2+) Signaling

Overview

Journal Biochemistry

Specialty Biochemistry

Date 2008 May 27

PMID 18500817

Citations 29

Authors

Venkateswar Venkataraman

Teresa Duda

Sarangan Ravichandran

Rameshwar K Sharma

Affiliations

Soon will be listed here.

Abstract

ROS-GC1 membrane guanylate cyclase is a Ca(2+) bimodal signal transduction switch. It is turned "off" by a rise in free Ca(2+) from nanomolar to the semicromolar range in the photoreceptor outer segments and the olfactory bulb neurons; by a similar rise in the bipolar and ganglion retinal neurons it is turned "on". These opposite operational modes of the switch are specified by its Ca(2+) sensing devices, respectively termed GCAPs and CD-GCAPs. Neurocalcin delta is a CD-GCAP. In the present study, the neurocalcin delta-modulated site, V(837)-L(858), in ROS-GC1 has been mapped. The location and properties of this site are unique. It resides within the core domain of the catalytic module and does not require the alpha-helical dimerization domain structural element (amino acids 767-811) for activating the catalytic module. Contrary to the current beliefs, the catalytic module is intrinsically active; it is directly regulated by the neurocalcin delta-modulated Ca(2+) signal and is dimeric in nature. A fold recognition based model of the catalytic domain of ROS-GC1 was built, and neurocalcin delta docking simulations were carried out to define the three-dimensional features of the interacting domains of the two molecules. These findings define a new transduction model for the Ca(2+) signaling of ROS-GC1.

Citing Articles

Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder.

Duda T, Sharma R Front Mol Neurosci. 2023; 15:1022771.

PMID: 36683846 PMC: 9849996. DOI: 10.3389/fnmol.2022.1022771.

Calcium-Dependent Translocation of S100B Is Facilitated by Neurocalcin Delta.

Zhang J, Krishnan A, Wu H, Venkataraman V Molecules. 2021; 26(1).

PMID: 33466232 PMC: 7794955. DOI: 10.3390/molecules26010227.

Ca-Sensor Neurocalcin δ and Hormone ANF Modulate ANF-RGC Activity by Diverse Pathways: Role of the Signaling Helix Domain.

Duda T, Pertzev A, Ravichandran S, Sharma R Front Mol Neurosci. 2018; 11:430.

PMID: 30546296 PMC: 6278801. DOI: 10.3389/fnmol.2018.00430.

CO/bicarbonate modulates cone photoreceptor ROS-GC1 and restores its CORD6-linked catalytic activity.

Duda T, Pertzev A, Sharma R Mol Cell Biochem. 2018; 448(1-2):91-105.

PMID: 29427171 PMC: 6687076. DOI: 10.1007/s11010-018-3317-9.

Membrane Guanylate Cyclase catalytic Subdomain: Structure and Linkage with Calcium Sensors and Bicarbonate.

Ravichandran S, Duda T, Pertzev A, Sharma R Front Mol Neurosci. 2017; 10:173.

PMID: 28638321 PMC: 5461267. DOI: 10.3389/fnmol.2017.00173.

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