» Articles » PMID: 18492791

Integrin-dependent Phagocytosis: Spreading from Microadhesion to New Concepts

Overview
Journal J Cell Sci
Specialty Cell Biology
Date 2008 May 22
PMID 18492791
Citations 129
Authors
Affiliations
Soon will be listed here.
Abstract

By linking actin dynamics to extracellular components, integrins are involved in a wide range of cellular processes that are associated with or require cytoskeletal remodelling and cell-shape changes. One such function is integrin-dependent phagocytosis, a process that several integrins are capable of mediating and that allows the binding and clearance of particles. Integrin-dependent phagocytosis is involved in a wide range of physiological processes, from the clearance of microorganisms and apoptotic-cell removal to extracellular-matrix remodelling. Integrin signalling is also exploited by microbial pathogens for entry into host cells. Far from being a particular property of specific integrins and specialised cells, integrin-dependent uptake is emerging as a general, intrinsic ability of most integrins that is associated with their capacity to signal to the actin cytoskeleton. Integrin-mediated phagocytosis can therefore be used as a robust model in which to study integrin regulation and signalling.

Citing Articles

Biological boundary conditions regulate the internalization of conidia by alveolar cells.

Schiefermeier-Mach N, Polleux J, Heinrich L, Lechner L, Vorona O, Perkhofer S Front Cell Infect Microbiol. 2025; 15:1515779.

PMID: 40066070 PMC: 11891256. DOI: 10.3389/fcimb.2025.1515779.


Biochemical and biophysical mechanisms macrophages use to tune phagocytic appetite.

Bond A, Morrissey M J Cell Sci. 2025; 138(1).

PMID: 39749603 PMC: 11828473. DOI: 10.1242/jcs.263513.


Toll-like receptors and integrins crosstalk.

Alhamdan F, Bayarsaikhan G, Yuki K Front Immunol. 2024; 15:1403764.

PMID: 38915411 PMC: 11194410. DOI: 10.3389/fimmu.2024.1403764.


Orientia tsutsugamushi: An Unusual Intracellular Bacteria-Adaptation Strategies, Available Antibiotics, and Alternatives for Treatment.

Srivastava P, Shukla A, Singh R, Kant R, Mishra N, Behera S Curr Microbiol. 2024; 81(8):236.

PMID: 38907107 DOI: 10.1007/s00284-024-03754-1.


Surface property and toxicity effect of insoluble particles given by protein corona: Implication for PM cytotoxicity assessment.

Chen S, Zhang Y, Chen H, Zheng W, Hu X, Mao L Eco Environ Health. 2024; 3(2):137-144.

PMID: 38638169 PMC: 11021833. DOI: 10.1016/j.eehl.2024.01.011.