Clonal Deletion of V Beta 14-bearing T Cells in Mice Transgenic for Mammary Tumour Virus

Overview

Journal Nature

Specialty Science

Date 1991 Mar 21

PMID 1848685

Citations 102

Authors

H Acha-Orbea

A N Shakhov

L Scarpellino

E Kolb

V Muller

R Fuchs

K Blochlinger

P Rollini

J Billotte

Affiliations

Soon will be listed here.

Abstract

Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.

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