P53, Cyclin-dependent Kinase and Abnormal Amplification of Centrosomes

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2008 May 13

PMID 18472015

Citations 42

Authors

Kenji Fukasawa

Affiliations

Soon will be listed here.

Abstract

Centrosomes play a critical role in formation of bipolar mitotic spindles, an essential event for accurate chromosome segregation into daughter cells. Numeral abnormalities of centrosomes (centrosome amplification) occur frequently in cancers, and are considered to be the major cause of chromosome instability, which accelerates acquisition of malignant phenotypes during tumor progression. Loss or mutational inactivation of p53 tumor suppressor protein, one of the most common mutations found in cancers, results in a high frequency of centrosome amplification in part via allowing the activation of the cyclin-dependent kinase (CDK) 2-cyclin E (as well as CDK2-cyclin A) which is a key factor for the initiation of centrosome duplication. In this review, the role of centrosome amplification in tumor progression, and mechanistic view of how centrosomes are amplified in cells through focusing on loss of p53 and aberrant activities of CDK2-cyclins will be discussed.

Citing Articles

MiR-597-5p suppresses the progression of hepatocellular carcinoma via targeting transcriptional enhancer associate domain transcription factor 1 (TEAD1).

Sun X, Hou Z, Li N, Zhang S In Vitro Cell Dev Biol Anim. 2022; 58(2):96-108.

PMID: 35169903 DOI: 10.1007/s11626-021-00614-1.

Utility and Mechanism of SHetA2 and Paclitaxel for Treatment of Endometrial Cancer.

Chandra V, Rai R, Benbrook D Cancers (Basel). 2021; 13(10).

PMID: 34066052 PMC: 8150795. DOI: 10.3390/cancers13102322.

MicroRNA-148a Regulates the Proliferation and Differentiation of Ovine Preadipocytes by Targeting .

Jin X, Hao Z, Zhao M, Shen J, Ke N, Song Y Animals (Basel). 2021; 11(3).

PMID: 33803986 PMC: 7998426. DOI: 10.3390/ani11030820.

Principal Postulates of Centrosomal Biology. Version 2020.

Uzbekov R, Avidor-Reiss T Cells. 2020; 9(10).

PMID: 32987651 PMC: 7598677. DOI: 10.3390/cells9102156.

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway.

Contadini C, Monteonofrio L, Virdia I, Prodosmo A, Valente D, Chessa L Cell Death Dis. 2019; 10(11):850.

PMID: 31699974 PMC: 6838180. DOI: 10.1038/s41419-019-2076-1.

References

Mussman J, Horn H, CARROLL P, Okuda M, Tarapore P, Donehower L . Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene. 2000; 19(13):1635-46. DOI: 10.1038/sj.onc.1203460. View

Duensing S, Lee L, Duensing A, Basile J, Piboonniyom S, Gonzalez S . The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc Natl Acad Sci U S A. 2000; 97(18):10002-7. PMC: 27652. DOI: 10.1073/pnas.170093297. View

Fisk H, Winey M . The mouse Mps1p-like kinase regulates centrosome duplication. Cell. 2001; 106(1):95-104. DOI: 10.1016/s0092-8674(01)00411-1. View

Kramer A, Mailand N, Lukas C, Syljuasen R, Wilkinson C, Nigg E . Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol. 2004; 6(9):884-91. DOI: 10.1038/ncb1165. View

Taylor W, Stark G . Regulation of the G2/M transition by p53. Oncogene. 2001; 20(15):1803-15. DOI: 10.1038/sj.onc.1204252. View

Hinchcliffe E, Sluder G . Two for two: Cdk2 and its role in centrosome doubling. Oncogene. 2002; 21(40):6154-60. DOI: 10.1038/sj.onc.1205826. View

Levine D, Sanchez C, Rabinovitch P, Reid B . Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer. Proc Natl Acad Sci U S A. 1991; 88(15):6427-31. PMC: 52098. DOI: 10.1073/pnas.88.15.6427. View

Hanashiro K, Kanai M, Geng Y, Sicinski P, Fukasawa K . Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells. Oncogene. 2008; 27(40):5288-302. PMC: 2574884. DOI: 10.1038/onc.2008.161. View

Chiba S, Okuda M, Mussman J, Fukasawa K . Genomic convergence and suppression of centrosome hyperamplification in primary p53-/- cells in prolonged culture. Exp Cell Res. 2000; 258(2):310-21. DOI: 10.1006/excr.2000.4916. View

10.

Ma Z, Kanai M, Kawamura K, Kaibuchi K, Ye K, Fukasawa K . Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol. 2006; 26(23):9016-34. PMC: 1636820. DOI: 10.1128/MCB.01383-06. View

11.

Nelsen C, Kuriyama R, Hirsch B, Negron V, Lingle W, Goggin M . Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy. J Biol Chem. 2004; 280(1):768-76. DOI: 10.1074/jbc.M407105200. View

12.

Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P . Cdk2 knockout mice are viable. Curr Biol. 2003; 13(20):1775-85. DOI: 10.1016/j.cub.2003.09.024. View

13.

Koff A, Giordano A, Desai D, Yamashita K, Harper J, Elledge S . Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science. 1992; 257(5077):1689-94. DOI: 10.1126/science.1388288. View

14.

Lacey K, Jackson P, Stearns T . Cyclin-dependent kinase control of centrosome duplication. Proc Natl Acad Sci U S A. 1999; 96(6):2817-22. PMC: 15852. DOI: 10.1073/pnas.96.6.2817. View

15.

Bornens M . Centrosome composition and microtubule anchoring mechanisms. Curr Opin Cell Biol. 2002; 14(1):25-34. DOI: 10.1016/s0955-0674(01)00290-3. View

16.

McDermott K, Zhang J, Holst C, Kozakiewicz B, Singla V, Tlsty T . p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol. 2006; 4(3):e51. PMC: 1361797. DOI: 10.1371/journal.pbio.0040051. View

17.

Charrier-Savournin F, Chateau M, Gire V, Sedivy J, Piette J, Dulic V . p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. Mol Biol Cell. 2004; 15(9):3965-76. PMC: 515331. DOI: 10.1091/mbc.e03-12-0871. View

18.

Nurse P . Universal control mechanism regulating onset of M-phase. Nature. 1990; 344(6266):503-8. DOI: 10.1038/344503a0. View

19.

Oikawa T, Okuda M, Ma Z, Goorha R, Tsujimoto H, Inokuma H . Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1. Mol Cell Biol. 2005; 25(10):4046-61. PMC: 1087701. DOI: 10.1128/MCB.25.10.4046-4061.2005. View

20.

Tarapore P, Horn H, Tokuyama Y, Fukasawa K . Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene. 2001; 20(25):3173-84. DOI: 10.1038/sj.onc.1204424. View