Twofold C-H Functionalization: Palladium-catalyzed Ortho Arylation of Anilides

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2008 May 10

PMID 18465866

Citations 39

Authors

Gordon Brasche

Jorge Garcia-Fortanet

Stephen L Buchwald

Affiliations

Soon will be listed here.

Abstract

The ortho arylation of anilides to form biphenyls via a twofold C-H functionalization/C-C bond-forming process is described. The oxidative coupling takes place in the presence of 5-10 mol % of Pd(OAc)2, 10-20 mol % of DMSO, and 4-11 equiv of the aryl substrate in TFA under an oxygen atmosphere. No metal-containing cocatalyst is required.

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