Intramolecular Pd(II)-catalyzed Aerobic Oxidative Amination of Alkenes: Synthesis of Six-membered N-heterocycles

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2012 Feb 24

PMID 22356620

Citations 15

Authors

Zhan Lu

Shannon S Stahl

Affiliations

Soon will be listed here.

Abstract

Use of a base-free Pd(DMSO)(2)(TFA)(2) catalyst system enables the synthesis of six-membered nitrogen heterocycles via a Wacker-type aerobic oxidative cyclization of alkenes bearing tethered sulfonamides. Various heterocycles, including morpholines, piperidines, piperazines, and piperazinones, are accessible by this method.

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