The Adipokine SAA3 is Induced by Interleukin-1beta in Mouse Adipocytes

Overview

Journal J Cell Biochem

Specialties Biochemistry
Cell Biology

Date 2008 May 3

PMID 18452164

Citations 20

Authors

Grit Sommer

Sebastian Weise

Susan Kralisch

Philipp E Scherer

Ulrike Lossner

Matthias Bluher

Michael Stumvoll

Mathias Fasshauer

Affiliations

Soon will be listed here.

Abstract

Serum amyloid A (SAA) 3 has been characterized as an inflammatory adipocyte-secreted acute-phase reactant. In the current study, regulation of SAA3 by the proinflammatory and insulin resistance-inducing cytokine interleukin (IL)-1beta was determined in 3T3-L1 and brown adipocytes. Interestingly, SAA3 mRNA and protein synthesis were dramatically increased by IL-1beta in a time-dependent fashion with maximal induction after 24 h. Furthermore, IL-1beta significantly induced SAA3 mRNA expression dose-dependently with maximal 36.4-fold upregulation seen at 2 ng/ml effector. Moreover, IL-1beta-induced SAA3 expression was mediated by nuclear factor-kappaB and janus kinase 2. Taken together, our data show a potent upregulation of SAA3 by IL-1beta.

Citing Articles

Serum amyloid A and metabolic disease: evidence for a critical role in chronic inflammatory conditions.

den Hartigh L, May K, Zhang X, Chait A, Blaser M Front Cardiovasc Med. 2023; 10:1197432.

PMID: 37396595 PMC: 10311072. DOI: 10.3389/fcvm.2023.1197432.

Serum amyloid A proteins reduce bone mass during mycobacterial infections.

Gomes A, Sousa D, Carvalho Oliveira T, Fonseca O, Pinto R, Silverio D Front Immunol. 2023; 14:1168607.

PMID: 37153579 PMC: 10161249. DOI: 10.3389/fimmu.2023.1168607.

The Association of Acute Phase Proteins in Stress and Inflammation-Induced T2D.

Speelman T, Dale L, Louw A, Verhoog N Cells. 2022; 11(14).

PMID: 35883605 PMC: 9321356. DOI: 10.3390/cells11142163.

Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA .

Engelhard C, Huang C, Khani S, Kasparek P, Prochazka J, Rozman J Noncoding RNA. 2022; 8(3).

PMID: 35645339 PMC: 9149892. DOI: 10.3390/ncrna8030032.

Sexually Dimorphic Relationships Among Saa3 (Serum Amyloid A3), Inflammation, and Cholesterol Metabolism Modulate Atherosclerosis in Mice.

Chait A, Wang S, Goodspeed L, Gomes D, Turk K, Wietecha T Arterioscler Thromb Vasc Biol. 2021; 41(6):e299-e313.

PMID: 33761762 PMC: 8159856. DOI: 10.1161/ATVBAHA.121.316066.