The Mych Gene is Required for Neural Crest Survival During Zebrafish Development

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2008 May 1

PMID 18446220

Citations 16

Authors

Sung-Kook Hong

Michael Tsang

Igor B Dawid

Affiliations

Soon will be listed here.

Abstract

Background: Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any developmental role of zebrafish Myc genes.

Principal Findings: We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain.

Significance: Mych is a novel factor required for neural crest cell survival in zebrafish.

Citing Articles

Mycb and Mych stimulate Müller glial cell reprogramming and proliferation in the uninjured and injured zebrafish retina.

Lee M, Jui J, Sahu A, Goldman D Development. 2024; 151(14).

PMID: 38984586 PMC: 11369687. DOI: 10.1242/dev.203062.

Genomic screening of fish-specific genes in gnathostomes and their functions in fin development.

Kudoh H, Yonei-Tamura S, Abe G, Iwakiri J, Uesaka M, Makino T Dev Growth Differ. 2024; 66(3):235-247.

PMID: 38439516 PMC: 11457510. DOI: 10.1111/dgd.12918.

An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution.

Howard 4th A, Baker P, Ibarra-Garcia-Padilla R, Moore J, Rivas L, Tallman J Elife. 2021; 10.

PMID: 33591267 PMC: 7886338. DOI: 10.7554/eLife.60005.

MYC in Brain Development and Cancer.

Zaytseva O, Kim N, Quinn L Int J Mol Sci. 2020; 21(20).

PMID: 33092025 PMC: 7588885. DOI: 10.3390/ijms21207742.

On the road again: Establishment and maintenance of stemness in the neural crest from embryo to adulthood.

Perera S, Kerosuo L Stem Cells. 2020; 39(1):7-25.

PMID: 33017496 PMC: 7821161. DOI: 10.1002/stem.3283.

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