Conformational Analysis of Polynucleotides. I. The Favorable Left-handed Helical Model for the Poly(8,2'-S-cycloadenylic Acid) with High Anti Conformation

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1976 Aug 1

PMID 184437

Citations 4

Authors

S Fujii

K Tomita

Affiliations

Soon will be listed here.

Abstract

1) Energy calculations have shown that poly (8,2'-S-cycloadenylic aicd) can form left-handed helices owing to the high anti conformation. 2) Two favorable left-handed helices are characterized by axial translation per residue (Z=4.3 and 3.6A) and by rotations per residue (theta= 40 degrees and -25 degrees). 3) The proposed helical models might be stable in aqueous solution and is well explicable of the optical property of this compound.

Citing Articles

Conformational characteristics of the dimeric subunits of DNA from energy minimization studies. Mixed sugar-puckered dApdA, dApdT, dTpdA, and dTpdT.

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Helix geometry of single stranded DNA 'A' and 'B' forms from minimum energy conformations of dimeric subunits.

Hingerty B, Broyde S Nucleic Acids Res. 1978; 5(1):127-37.

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The influence of terminal 3', 5' phosphates on conformations of dApdA.

Broyde S, Hingerty B Nucleic Acids Res. 1979; 6(6):2165-78.

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Spatial configuration of ordered polynucleotide chains: a novel double helix.

Olson W Proc Natl Acad Sci U S A. 1977; 74(5):1775-9.

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