Modifiable Risk Factors for Invasive Meningococcal Disease During an Edmonton, Alberta Outbreak, 1999-2002

Overview

Journal Can J Public Health

Publisher Springer Nature

Specialty Public Health

Date 2008 Apr 26

PMID 18435391

Citations 4

Authors

Lance Honish

Colin L Soskolne

Ambikaipakan Senthilselvan

Stan Houston

Affiliations

Soon will be listed here.

Abstract

Background: An outbreak of invasive meningococcal disease (IMD) in metro Edmonton, Alberta, Canada between December 1999 and June 2002 resulted in 84 laboratory-confirmed cases. Most cases were infected with Neisseria meningitidis serogroup C, and the highest age-specific incidence was observed in the 15-19 year age group.

Methods: A case-control study was conducted to identify modifiable IMD risk factors among outbreak cases. Two controls were matched to each case on age and sex, and were recruited through random-digit dialing. A questionnaire was telephone-administered to 132 study participants (44 cases, 88 controls). Conditional logistic regression was utilized to calculate risk measures.

Results: Multivariate analysis revealed three statistically significant risk factors: bar patronage (OR 35.2; 95% CI: 2.64-468), "rave" attendance (OR 12.8; 95% CI: 1.47-111) and maternal smoking (OR 8.88; 95% CI: 1.67-47.4). Humidifier use in the home was protective (OR 0.07; 95% CI: 0.009-0.64).

Conclusion: While the precision of risk estimates was low in the multivariate model, this study has identified rave attendance as an emergent IMD risk factor.

Citing Articles

Invasive Meningococcal Disease on the Workplaces: a systematic review.

Ricco M, Vezzosi L, Odone A, Signorelli C Acta Biomed. 2017; 88(3):337-351.

PMID: 29083344 PMC: 6142849. DOI: 10.23750/abm.v88i3.6726.

Second hand smoke exposure and the risk of invasive meningococcal disease in children: systematic review and meta-analysis.

Murray R, Britton J, Leonardi-Bee J BMC Public Health. 2012; 12:1062.

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Association of secondhand smoke exposure with pediatric invasive bacterial disease and bacterial carriage: a systematic review and meta-analysis.

Lee C, Middaugh N, Howie S, Ezzati M PLoS Med. 2010; 7(12):e1000374.

PMID: 21151890 PMC: 2998445. DOI: 10.1371/journal.pmed.1000374.

Modifiable risk factors for invasive meningococcal disease during an Edmonton, Alberta outbreak, 1999-2002.

Honish L, Soskolne C, Senthilselvan A, Houston S Can J Public Health. 2008; 99(1):46-51.

PMID: 18435391 PMC: 6976143.

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