Cardiac Thin Filament Regulation

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2008 Apr 19

PMID 18421471

Citations 44

Authors

Tomoyoshi Kobayashi

Lei Jin

Pieter P de Tombe

Affiliations

Soon will be listed here.

Abstract

Myocardial contraction is initiated upon the release of calcium into the cytosol from the sarcoplasmic reticulum following membrane depolarization. The fundamental physiological role of the heart is to pump an amount blood that is determined by the prevailing requirements of the body. The physiological control systems employed to accomplish this task include regulation of heart rate, the amount of calcium release, and the response of the cardiac myofilaments to activator calcium ions. Thin filament activation and relaxation dynamics has emerged as a pivotal regulatory system tuning myofilament function to the beat-to-beat regulation of cardiac output. Maladaptation of thin filament dynamics, in addition to dysfunctional calcium cycling, is now recognized as an important cellular mechanism causing reduced cardiac pump function in a variety of cardiac diseases. Here, we review current knowledge regarding protein-protein interactions involved in the dynamics of thin filament activation and relaxation and the regulation of these processes by protein kinase-mediated phosphorylation.

Citing Articles

Altering Calcium Sensitivity in Heart Failure: A Crossroads of Disease Etiology and Therapeutic Innovation.

Saad N, Mashali M, Repas S, Janssen P Int J Mol Sci. 2023; 24(24).

PMID: 38139404 PMC: 10744146. DOI: 10.3390/ijms242417577.

High hydrostatic pressure induces slow contraction in mouse cardiomyocytes.

Yamaguchi Y, Nishiyama M, Kai H, Kaneko T, Kaihara K, Iribe G Biophys J. 2022; 121(17):3286-3294.

PMID: 35841143 PMC: 9463647. DOI: 10.1016/j.bpj.2022.07.016.

The Cardiomyocyte in Heart Failure with Preserved Ejection Fraction-Victim of Its Environment?.

Rocca A, van Heeswijk R, Richiardi J, Meyer P, Hullin R Cells. 2022; 11(5).

PMID: 35269489 PMC: 8909081. DOI: 10.3390/cells11050867.

Troponin Variants in Congenital Myopathies: How They Affect Skeletal Muscle Mechanics.

van de Locht M, Borsboom T, Winter J, Ottenheijm C Int J Mol Sci. 2021; 22(17).

PMID: 34502093 PMC: 8430961. DOI: 10.3390/ijms22179187.

Clinical and Diagnostic Value of Highly Sensitive Cardiac Troponins in Arterial Hypertension.

Chaulin A Vasc Health Risk Manag. 2021; 17:431-443.

PMID: 34366667 PMC: 8336985. DOI: 10.2147/VHRM.S315376.

References

Farman G, Walker J, de Tombe P, Irving T . Impact of osmotic compression on sarcomere structure and myofilament calcium sensitivity of isolated rat myocardium. Am J Physiol Heart Circ Physiol. 2006; 291(4):H1847-55. DOI: 10.1152/ajpheart.01237.2005. View

Engel P, Kobayashi T, Biesiadecki B, Davis J, Tikunova S, Wu S . Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments. J Biol Chem. 2006; 282(1):183-93. DOI: 10.1074/jbc.M512337200. View

Anderson P, Greig A, Mark T, Malouf N, Oakeley A, Ungerleider R . Molecular basis of human cardiac troponin T isoforms expressed in the developing, adult, and failing heart. Circ Res. 1995; 76(4):681-6. DOI: 10.1161/01.res.76.4.681. View

Geeves M, Holmes K . The molecular mechanism of muscle contraction. Adv Protein Chem. 2005; 71:161-93. DOI: 10.1016/S0065-3233(04)71005-0. View

Abbott M, Dong W, Dvoretsky A, Dague B, Caprioli R, Cheung H . Modulation of cardiac troponin C-cardiac troponin I regulatory interactions by the amino-terminus of cardiac troponin I. Biochemistry. 2001; 40(20):5992-6001. DOI: 10.1021/bi0100642. View

Tachampa K, Wang H, Farman G, de Tombe P . Cardiac troponin I threonine 144: role in myofilament length dependent activation. Circ Res. 2007; 101(11):1081-3. DOI: 10.1161/CIRCRESAHA.107.165258. View

Reiffert S, Jaquet K, Heilmeyer Jr L, Ritchie M, Geeves M . Bisphosphorylation of cardiac troponin I modulates the Ca(2+)-dependent binding of myosin subfragment S1 to reconstituted thin filaments. FEBS Lett. 1996; 384(1):43-7. DOI: 10.1016/0014-5793(96)00274-8. View

Kruger M, Zittrich S, Redwood C, Blaudeck N, James J, Robbins J . Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils. J Physiol. 2005; 564(Pt 2):347-57. PMC: 1464436. DOI: 10.1113/jphysiol.2004.079095. View

Tardiff J . Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes. Heart Fail Rev. 2006; 10(3):237-48. DOI: 10.1007/s10741-005-5253-5. View

10.

Solaro R, Rosevear P, Kobayashi T . The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation. Biochem Biophys Res Commun. 2007; 369(1):82-7. PMC: 2365727. DOI: 10.1016/j.bbrc.2007.12.114. View

11.

Farman G, Allen E, Gore D, Irving T, de Tombe P . Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae. Biophys J. 2007; 92(9):L73-5. PMC: 1852334. DOI: 10.1529/biophysj.107.104257. View

12.

Blumenschein T, Stone D, Fletterick R, Mendelson R, Sykes B . Dynamics of the C-terminal region of TnI in the troponin complex in solution. Biophys J. 2006; 90(7):2436-44. PMC: 1403181. DOI: 10.1529/biophysj.105.076216. View

13.

Day S, Westfall M, Fomicheva E, Hoyer K, Yasuda S, La Cross N . Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Nat Med. 2006; 12(2):181-9. DOI: 10.1038/nm1346. View

14.

Pyle W, Sumandea M, Solaro R, de Tombe P . Troponin I serines 43/45 and regulation of cardiac myofilament function. Am J Physiol Heart Circ Physiol. 2002; 283(3):H1215-24. DOI: 10.1152/ajpheart.00128.2002. View

15.

Jaquet K, Lohmann K, Czisch M, Holak T, Gulati J, Jaquet R . A model for the function of the bisphosphorylated heart-specific troponin-I N-terminus. J Muscle Res Cell Motil. 1998; 19(6):647-59. DOI: 10.1023/a:1005381131102. View

16.

Belin R, Sumandea M, Allen E, Schoenfelt K, Wang H, Solaro R . Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Circ Res. 2007; 101(2):195-204. DOI: 10.1161/CIRCRESAHA.107.148288. View

17.

de Tombe P, Solaro R . Integration of cardiac myofilament activity and regulation with pathways signaling hypertrophy and failure. Ann Biomed Eng. 2001; 28(8):991-1001. DOI: 10.1114/1.1312189. View

18.

Arteaga G, Palmiter K, Leiden J, Solaro R . Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I. J Physiol. 2000; 526 Pt 3:541-9. PMC: 2270032. DOI: 10.1111/j.1469-7793.2000.t01-1-00541.x. View

19.

Sano K, Maeda K, Oda T, Maeda Y . The effect of single residue substitutions of serine-283 on the strength of head-to-tail interaction and actin binding properties of rabbit skeletal muscle alpha-tropomyosin. J Biochem. 2000; 127(6):1095-102. DOI: 10.1093/oxfordjournals.jbchem.a022703. View

20.

Tregear R, Reedy M, Goldman Y, Taylor K, Winkler H, Franzini-Armstrong C . Cross-bridge number, position, and angle in target zones of cryofixed isometrically active insect flight muscle. Biophys J. 2004; 86(5):3009-19. PMC: 1304167. DOI: 10.1016/S0006-3495(04)74350-7. View