Silk-based Electrospun Tubular Scaffolds for Tissue-engineered Vascular Grafts

Overview

Journal J Biomater Sci Polym Ed

Specialty Biomedical Engineering

Date 2008 Apr 19

PMID 18419943

Citations 72

Authors

Leah Soffer

Xianyan Wang

Xiaohui Zhang

Jonathan Kluge

Luis Dorfmann

David L Kaplan

Gary Leisk

Affiliations

Soon will be listed here.

Abstract

Electrospinning was used to fabricate non-woven nanofibrous tubular scaffolds from Bombyx mori silk fibroin using an all aqueous process. Cell studies and mechanical characterization tests were performed on the electrospun silk tubes to assess the viability of their usage in bioengineering small-diameter vascular grafts. Human endothelial cells and smooth muscle cells were successfully cultured on the electrospun silk. Mechanical characterization tests demonstrated burst strength sufficient to withstand arterial pressures and tensile properties comparable to native vessels. These cellular and mechanics outcomes demonstrate potential utility of these electrospun silk scaffolds for small-diameter vascular grafts.

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