Organocatalytic Asymmetric Transfer Hydrogenation in Aqueous Media Using Resin-supported Peptide Having a Polyleucine Tether
Overview
Chemistry
Affiliations
A resin-supported N-terminal prolyl peptide having a beta-turn motif and hydrophobic polyleucine chain effectively catalyzed the asymmetric transfer hydrogenation under aqueous conditions. The polyleucine tether provides a hydrophobic cavity in aqueous media that brought about a remarkable acceleration of the reaction. In addition, the polyleucine chain also turned out to be essential for high enantioselectivity.
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