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In Vitro Replication of Varicella-zoster Virus in Human Retinal Pigment Epithelial Cells

Overview
Journal J Clin Microbiol
Specialty Microbiology
Date 2008 Apr 11
PMID 18400911
Citations 12
Authors
Jonas Schmidt-Chanasit
Karoline Bleymehl
Holger F Rabenau
Rainer G Ulrich
Jindrich Cinatl Jr
Hans Wilhelm Doerr
Affiliations
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Abstract

Here we describe for the first time the productive in vitro infection of human retinal pigment epithelial cells by varicella-zoster virus (VZV), resulting in a typical cytopathic effect (CPE) that is characterized by enlarged cells with increased granularity. Depending on the CPE dissemination, high titers of up to 1.6 x 10(6) PFU of cell-free and cryostable VZV/ml can be recovered.

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