A Novel Function of CD82/KAI-1 on E-cadherin-mediated Homophilic Cellular Adhesion of Cancer Cells

Overview

Journal Cancer Lett

Specialty Oncology

Date 2008 Apr 9

PMID 18395972

Citations 37

Authors

Masakazu Abe

Tsuyoshi Sugiura

Miho Takahashi

Kotaro Ishii

Miyuki Shimoda

Kanemitsu Shirasuna

Affiliations

Soon will be listed here.

Abstract

In this study, we analyzed the effect of the metastasis suppressor CD82/KAI-1, a member of the tetraspanin superfamily, on intercellular adhesion on cancer cells. The newly established invasion assay and the cell aggregation assay revealed that CD82 strengthens E-cadherin-mediated intercellular adhesion. Interestingly, ectopic expression of CD82 stabilized E-cadherin/beta-catenin complex formation. Furthermore, CD82 reduced tyrosine phosphorylation of beta-catenin on HGF stimulation. Taken together, CD82 may stabilize or strengthen E-cadherin-dependent intercellular adhesion by regulating beta-catenin-mediated signal transduction on cancer cells, and consequently, prevent cancer cells from seceding from the primary tumor site.

Citing Articles

Tetraspanins: Novel Molecular Regulators of Gastric Cancer.

Deng Y, Cai S, Shen J, Peng H Front Oncol. 2021; 11:702510.

PMID: 34222025 PMC: 8250138. DOI: 10.3389/fonc.2021.702510.

Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer.

Al-Khater K, Almofty S, Ravinayagam V, Alrushaid N, Rehman S Saudi J Biol Sci. 2021; 28(6):3391-3398.

PMID: 34121877 PMC: 8176039. DOI: 10.1016/j.sjbs.2021.03.001.

Gene expression analysis of human prostate cell lines with and without tumor metastasis suppressor CD82.

Dodla P, Bhoopalan V, Khoo S, Miranti C, Sridhar S BMC Cancer. 2020; 20(1):1211.

PMID: 33298014 PMC: 7724878. DOI: 10.1186/s12885-020-07675-7.

CD82 Suppresses ADAM17-Dependent E-Cadherin Cleavage and Cell Migration in Prostate Cancer.

Ma Z, Gao Y, Liu W, Zheng L, Jin B, Duan B Dis Markers. 2020; 2020:8899924.

PMID: 33204367 PMC: 7654213. DOI: 10.1155/2020/8899924.

MGAT3-mediated glycosylation of tetraspanin CD82 at asparagine 157 suppresses ovarian cancer metastasis by inhibiting the integrin signaling pathway.

Li J, Xu J, Li L, Ianni A, Kumari P, Liu S Theranostics. 2020; 10(14):6467-6482.

PMID: 32483464 PMC: 7255015. DOI: 10.7150/thno.43865.