Epigenetic Regulation of Mammalian Stem Cells

Overview

Journal Stem Cells Dev

Date 2008 Apr 9

PMID 18393635

Citations 34

Authors

Xuekun Li

Xinyu Zhao

Affiliations

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Abstract

Two critical properties of stem cells are self-renewal and multipotency. The maintenance of their "stemness" state and commitment to differentiation are therefore tightly controlled by intricate molecular networks. Epigenetic mechanisms, including DNA methylation, chromatin remodeling and the noncoding RNA-mediated process, have profound regulatory roles in mammalian gene expression. Recent studies have shown that epigenetic regulators are key players in stem cell biology and their dysfunction can result in human diseases such as cancer and neurodevelopmental disorders. Here, we review the recent evidences that advance our knowledge in epigenetic regulations of mammalian stem cells, with focus on embryonic stem cells and neural stem cells.

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References

Ahn S, Joyner A . In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature. 2005; 437(7060):894-7. DOI: 10.1038/nature03994. View

Sansom O, Berger J, Bishop S, Hendrich B, Bird A, Clarke A . Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet. 2003; 34(2):145-7. DOI: 10.1038/ng1155. View

Bartel D . MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116(2):281-97. DOI: 10.1016/s0092-8674(04)00045-5. View

Robertson K, Ait-Si-Ali S, Yokochi T, Wade P, Jones P, Wolffe A . DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet. 2000; 25(3):338-42. DOI: 10.1038/77124. View

Smrt R, Eaves-Egenes J, Barkho B, Santistevan N, Zhao C, Aimone J . Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis. 2007; 27(1):77-89. PMC: 2789309. DOI: 10.1016/j.nbd.2007.04.005. View

Hansen R, Wijmenga C, Luo P, Stanek A, Canfield T, Weemaes C . The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc Natl Acad Sci U S A. 1999; 96(25):14412-7. PMC: 24450. DOI: 10.1073/pnas.96.25.14412. View

Okita K, Ichisaka T, Yamanaka S . Generation of germline-competent induced pluripotent stem cells. Nature. 2007; 448(7151):313-7. DOI: 10.1038/nature05934. View

Valk-Lingbeek M, Bruggeman S, van Lohuizen M . Stem cells and cancer; the polycomb connection. Cell. 2004; 118(4):409-18. DOI: 10.1016/j.cell.2004.08.005. View

Wu H, Xu J, Pang Z, Ge W, Kim K, Blanchi B . Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A. 2007; 104(34):13821-6. PMC: 1959466. DOI: 10.1073/pnas.0706199104. View

10.

Hu K, Nan X, Bird A, Wang W . Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex. Nat Genet. 2006; 38(9):962-4. DOI: 10.1038/ng0906-962. View

11.

Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, Yanagisawa M . DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell. 2001; 1(6):749-58. DOI: 10.1016/s1534-5807(01)00101-0. View

12.

Shihabuddin L, Horner P, Ray J, Gage F . Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci. 2000; 20(23):8727-35. PMC: 6773057. View

13.

Pencea V, Bingaman K, Freedman L, Luskin M . Neurogenesis in the subventricular zone and rostral migratory stream of the neonatal and adult primate forebrain. Exp Neurol. 2001; 172(1):1-16. DOI: 10.1006/exnr.2001.7768. View

14.

Hsieh J, Nakashima K, Kuwabara T, Mejia E, Gage F . Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci U S A. 2004; 101(47):16659-64. PMC: 527137. DOI: 10.1073/pnas.0407643101. View

15.

Thatcher K, LaSalle J . Dynamic changes in Histone H3 lysine 9 acetylation localization patterns during neuronal maturation require MeCP2. Epigenetics. 2007; 1(1):24-31. PMC: 1857283. DOI: 10.4161/epi.1.1.2339. View

16.

Shi Y, Lie D, Taupin P, Nakashima K, Ray J, Yu R . Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004; 427(6969):78-83. DOI: 10.1038/nature02211. View

17.

Cameron H, Tanapat P, Gould E . Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neuroscience. 1998; 82(2):349-54. DOI: 10.1016/s0306-4522(97)00303-5. View

18.

Ashraf S, McLoon A, Sclarsic S, Kunes S . Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila. Cell. 2006; 124(1):191-205. DOI: 10.1016/j.cell.2005.12.017. View

19.

Hall I, Shankaranarayana G, Noma K, Ayoub N, Cohen A, Grewal S . Establishment and maintenance of a heterochromatin domain. Science. 2002; 297(5590):2232-7. DOI: 10.1126/science.1076466. View

20.

Nan X, Ng H, Johnson C, Laherty C, Turner B, Eisenman R . Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature. 1998; 393(6683):386-9. DOI: 10.1038/30764. View