Effects of Green Tea Fractions on Oxygen-induced Retinal Neovascularization in the Neonatal Rat

Overview

Journal J Clin Biochem Nutr

Specialty Biochemistry

Date 2008 Apr 9

PMID 18392105

Citations 8

Authors

Yuta Saito

Yasuko Hasebe-Takenaka

Toshihiko Ueda

Takako Nakanishi-Ueda

Shotaro Kosuge

Masaki Aburada

Tsutomu Shimada

Yukinobu Ikeya

Hidetoshi Onda

Hirotsugu Ogura

Yoko Taguchi

Hajime Yasuhara

Ryohei Koide

Affiliations

Soon will be listed here.

Abstract

This study aimed to investigate the preventive effects of green tea fractions (GTFs) on rat model of oxygen-induced retinopathy (OIR). Neonatal Sprague-Dawley rats were exposed to daily cycles of 80% oxygen (20.5 h), ambient air (0.5 h), and progressive return to 80% oxygen (3 h) until postnatal day 12 (P12), then the rats were placed in ambient air until P18. The green tea was fractionated by DM-A50, DM-W, M-B, and M-W. The rats were treated once daily from P6 to P17 by gastric gavage of GTFs (0.05 or 0.01 g/ml) or distilled water (DW) at 50 microl/10 g body weight. On P18, the rats were sacrificed and the retinal samples were collected. The retinal neovascularization (NV) was scored and avascular areas (AVAs) were measured as a % of total retinal area (%AVAs) in ADPase stained retinas. The NV scores in 0.01 g/ml M-W were significantly lower than those in DW. The %AVAs in 0.05 g/ml DM-A50 and in 0.05 g/ml and 0.01 g/ml M-W were significantly lower than those in DW. There were less catechins, and less caffeine in M-W fraction compared with other GTFs, suggesting components of green tea except for catechins and caffeine might suppress the neovascularization in rat model of OIR.

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