Asymmetric Organocatalytic Three-component 1,3-dipolar Cycloaddition: Control of Stereochemistry Via a Chiral Brønsted Acid Activated Dipole

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2008 Apr 5

PMID 18386896

Citations 13

Authors

Xiao-Hua Chen

Wen-Quan Zhang

Liu-Zhu Gong

Affiliations

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Abstract

A Brønsted acid catalyzed three-component asymmetric 1,3-dipolar addition reaction between aldehydes, amino esters, and dipolarophiles by a new bisphosphoric acid, derived from the linked BINOL, furnished multiply substituted pyrrolidines in high yield with excellent enantioselectivities under mild conditions.

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