MicroRNA-206: the Skeletal Muscle-specific MyomiR

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2008 Apr 3

PMID 18381085

Citations 214

Authors

John J McCarthy

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myomiRs (myo=muscle+miR=miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in myogenesis as well as propose potential new roles for miR-206 in skeletal muscle biology. The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle.

Citing Articles

Brain-Periphery Axes: The Potential Role of Extracellular Vesicles-Delivered miRNAs.

DAmico G, Carista A, Manna O, Paladino L, Picone D, Sarullo S Biology (Basel). 2025; 13(12.

PMID: 39765723 PMC: 11673379. DOI: 10.3390/biology13121056.

miRNA-1 regulation is necessary for mechanical overload-induced muscle hypertrophy in male mice.

Fei S, Rule B, Godwin J, Mobley C, Roberts M, von Walden F Physiol Rep. 2025; 13(1):e70166.

PMID: 39761956 PMC: 11705529. DOI: 10.14814/phy2.70166.

Muscle-Derived Bioactive Factors: MyoEVs and Myokines.

Liu X, Yao Z, Zhang L, Shyh-Chang N Cell Prolif. 2024; 58(3):e13801.

PMID: 39737773 PMC: 11882754. DOI: 10.1111/cpr.13801.

Regulation of miR-206 in denervated and dystrophic muscles, and its effect on acetylcholine receptor clustering.

Barden J, Kosloski O, Jadidian A, Akaaboune M J Cell Sci. 2024; 137(24).

PMID: 39575567 PMC: 11795291. DOI: 10.1242/jcs.262303.

CircRNA profiling of skeletal muscle satellite cells in goats reveals circTGFβ2 promotes myoblast differentiation.

Zhan S, Jiang R, An Z, Zhang Y, Zhong T, Wang L BMC Genomics. 2024; 25(1):1075.

PMID: 39533172 PMC: 11555921. DOI: 10.1186/s12864-024-11008-4.

References

Darnell D, Kaur S, Stanislaw S, Konieczka J, Konieczka J, Yatskievych T . MicroRNA expression during chick embryo development. Dev Dyn. 2006; 235(11):3156-65. DOI: 10.1002/dvdy.20956. View

Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller M . Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005; 132(9):2235-49. DOI: 10.1242/dev.01773. View

Kim H, Lee Y, Sivaprasad U, Malhotra A, Dutta A . Muscle-specific microRNA miR-206 promotes muscle differentiation. J Cell Biol. 2006; 174(5):677-87. PMC: 2064311. DOI: 10.1083/jcb.200603008. View

Yang X, Vogan K, Gros P, Park M . Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice. Development. 1996; 122(7):2163-71. DOI: 10.1242/dev.122.7.2163. View

Kwon C, Han Z, Olson E, Srivastava D . MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A. 2005; 102(52):18986-91. PMC: 1315275. DOI: 10.1073/pnas.0509535102. View

Ji J, Tsika G, Rindt H, Schreiber K, McCarthy J, Kelm Jr R . Puralpha and Purbeta collaborate with Sp3 to negatively regulate beta-myosin heavy chain gene expression during skeletal muscle inactivity. Mol Cell Biol. 2006; 27(4):1531-43. PMC: 1800711. DOI: 10.1128/MCB.00629-06. View

Xu S, Witmer P, Lumayag S, Kovacs B, Valle D . MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. J Biol Chem. 2007; 282(34):25053-66. DOI: 10.1074/jbc.M700501200. View

Wienholds E, Kloosterman W, Miska E, Alvarez-Saavedra E, Berezikov E, de Bruijn E . MicroRNA expression in zebrafish embryonic development. Science. 2005; 309(5732):310-1. DOI: 10.1126/science.1114519. View

McPherron A, Lawler A, Lee S . Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997; 387(6628):83-90. DOI: 10.1038/387083a0. View

10.

Lim L, Lau N, Garrett-Engele P, Grimson A, Schelter J, Castle J . Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005; 433(7027):769-73. DOI: 10.1038/nature03315. View

11.

Sempere L, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V . Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 2004; 5(3):R13. PMC: 395763. DOI: 10.1186/gb-2004-5-3-r13. View

12.

Saunders M, Liang H, Li W . Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci U S A. 2007; 104(9):3300-5. PMC: 1805605. DOI: 10.1073/pnas.0611347104. View

13.

Rao P, Kumar R, Farkhondeh M, Baskerville S, Lodish H . Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A. 2006; 103(23):8721-6. PMC: 1482645. DOI: 10.1073/pnas.0602831103. View

14.

Liang Y, Ridzon D, Wong L, Chen C . Characterization of microRNA expression profiles in normal human tissues. BMC Genomics. 2007; 8:166. PMC: 1904203. DOI: 10.1186/1471-2164-8-166. View

15.

Shingara J, Keiger K, Shelton J, Laosinchai-Wolf W, Powers P, Conrad R . An optimized isolation and labeling platform for accurate microRNA expression profiling. RNA. 2005; 11(9):1461-70. PMC: 1370829. DOI: 10.1261/rna.2610405. View

16.

Georges M, Clop A, Marcq F, Takeda H, Pirottin D, Hiard S . Polymorphic microRNA-target interactions: a novel source of phenotypic variation. Cold Spring Harb Symp Quant Biol. 2007; 71:343-50. DOI: 10.1101/sqb.2006.71.056. View

17.

Iorio M, Ferracin M, Liu C, Veronese A, Spizzo R, Sabbioni S . MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005; 65(16):7065-70. DOI: 10.1158/0008-5472.CAN-05-1783. View

18.

Schiaffino S, Sandri M, Murgia M . Activity-dependent signaling pathways controlling muscle diversity and plasticity. Physiology (Bethesda). 2007; 22:269-78. DOI: 10.1152/physiol.00009.2007. View

19.

Anderson C, Catoe H, Werner R . MIR-206 regulates connexin43 expression during skeletal muscle development. Nucleic Acids Res. 2006; 34(20):5863-71. PMC: 1635318. DOI: 10.1093/nar/gkl743. View

20.

Boutz P, Chawla G, Stoilov P, Black D . MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Genes Dev. 2007; 21(1):71-84. PMC: 1759902. DOI: 10.1101/gad.1500707. View