Palladium-catalyzed Intramolecular C-arylation of Benzylic Carbon: Synthesis of 3-benzoxazolylisoindolinones by a Sequence of Ugi-4CR/postfunctionalization

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2008 Apr 3

PMID 18380480

Citations 7

Authors

Angela Salcedo

Luc Neuville

Jieping Zhu

Affiliations

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Abstract

Submitting Ugi-adduct 4 to two consecutive metal-catalyzed intramolecular reactions, namely copper-catalyzed O-arylation and palladium-catalyzed C-arylation of benzylic carbon developed in the course of this study, affords the benzoxazolylisoindolinones in good to excellent yields.

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