Aging Stem Cells, Latexin, and Longevity

Overview

Journal Exp Cell Res

Specialty Cell Biology

Date 2008 Apr 1

PMID 18374916

Citations 24

Authors

Ying Liang

Gary van Zant

Affiliations

Soon will be listed here.

Citing Articles

Latexin deficiency limits foam cell formation and ameliorates atherosclerosis by promoting macrophage phenotype differentiation.

He G, Ni Y, Hua R, Wan H, Tan Y, Chen Q Cell Death Dis. 2024; 15(10):754.

PMID: 39424784 PMC: 11492231. DOI: 10.1038/s41419-024-07141-3.

Loss of LXN promotes macrophage M2 polarization and PD-L2 expression contributing cancer immune-escape in mice.

Li Y, Tan Y, Li X, Chen X, Wang L, Zhang L Cell Death Discov. 2022; 8(1):440.

PMID: 36323670 PMC: 9630456. DOI: 10.1038/s41420-022-01227-7.

The regulatory function of piRNA/PIWI complex in cancer and other human diseases: The role of DNA methylation.

Jia D, Jiang H, Zhang Y, Zhang Y, Qian L, Zhang Y Int J Biol Sci. 2022; 18(8):3358-3373.

PMID: 35637965 PMC: 9134905. DOI: 10.7150/ijbs.68221.

LXN deficiency regulates cytoskeleton remodelling by promoting proteolytic cleavage of Filamin A in vascular endothelial cells.

He G, Kan S, Xu S, Sun X, Li R, Shu W J Cell Mol Med. 2021; 25(14):6815-6827.

PMID: 34085389 PMC: 8278077. DOI: 10.1111/jcmm.16685.

Breast Cancer and the Other Non-Coding RNAs.

Dvorska D, Brany D, nachajova M, Halasova E, Dankova Z Int J Mol Sci. 2021; 22(6).

PMID: 33807045 PMC: 8005115. DOI: 10.3390/ijms22063280.

References

Liang Y, van Zant G, Szilvassy S . Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood. 2005; 106(4):1479-87. PMC: 1895199. DOI: 10.1182/blood-2004-11-4282. View

Garcia-Castellanos R, Bonet-Figueredo R, Pallares I, VENTURA S, Aviles F, Vendrell J . Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin. Cell Mol Life Sci. 2005; 62(17):1996-2014. PMC: 11139196. DOI: 10.1007/s00018-005-5174-4. View

Domen J, Cheshier S, Weissman I . The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential. J Exp Med. 2000; 191(2):253-64. PMC: 2195763. DOI: 10.1084/jem.191.2.253. View

Ross E, Anderson N, Micklem H . Serial depletion and regeneration of the murine hematopoietic system. Implications for hematopoietic organization and the study of cellular aging. J Exp Med. 1982; 155(2):432-44. PMC: 2186603. DOI: 10.1084/jem.155.2.432. View

Sokol J, Schiemann W . Cystatin C antagonizes transforming growth factor beta signaling in normal and cancer cells. Mol Cancer Res. 2004; 2(3):183-95. View

Harman D . Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3):298-300. DOI: 10.1093/geronj/11.3.298. View

Liang Y, Jansen M, Aronow B, Geiger H, van Zant G . The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice. Nat Genet. 2007; 39(2):178-88. DOI: 10.1038/ng1938. View

Huh C, Hakansson K, Nathanson C, Thorgeirsson U, Jonsson N, Grubb A . Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene. Mol Pathol. 2000; 52(6):332-40. PMC: 395718. DOI: 10.1136/mp.52.6.332. View

Campisi J . Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol. 2003; 38(1-2):5-11. DOI: 10.1016/s0531-5565(02)00152-3. View

10.

Finkel T, Serrano M, Blasco M . The common biology of cancer and ageing. Nature. 2007; 448(7155):767-74. DOI: 10.1038/nature05985. View

11.

Bradford G, Williams B, Rossi R, Bertoncello I . Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment. Exp Hematol. 1997; 25(5):445-53. View

12.

Dill K, Chan H . From Levinthal to pathways to funnels. Nat Struct Biol. 1997; 4(1):10-9. DOI: 10.1038/nsb0197-10. View

13.

Siminovitch L, Till J, McCulloch E . DECLINE IN COLONY-FORMING ABILITY OF MARROW CELLS SUBJECTED TO SERIAL TRANSPLANTATION INTO IRRADIATED MICE. J Cell Comp Physiol. 1964; 64:23-31. DOI: 10.1002/jcp.1030640104. View

14.

Morrison S, Wandycz A, Akashi K, Globerson A, Weissman I . The aging of hematopoietic stem cells. Nat Med. 1996; 2(9):1011-6. DOI: 10.1038/nm0996-1011. View

15.

Allsopp R, Cheshier S, Weissman I . Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. J Exp Med. 2001; 193(8):917-24. PMC: 2193408. DOI: 10.1084/jem.193.8.917. View

16.

Nagai A, Kobayashi S, Shimode K, Imaoka K, Umegae N, Fujihara S . No mutations in cystatin C gene in cerebral amyloid angiopathy with cystatin C deposition. Mol Chem Neuropathol. 1998; 33(1):63-78. DOI: 10.1007/BF02815860. View

17.

Yuan R, Astle C, Chen J, Harrison D . Genetic regulation of hematopoietic stem cell exhaustion during development and growth. Exp Hematol. 2005; 33(2):243-50. DOI: 10.1016/j.exphem.2004.10.014. View

18.

Smith L, Weissman I, Heimfeld S . Clonal analysis of hematopoietic stem-cell differentiation in vivo. Proc Natl Acad Sci U S A. 1991; 88(7):2788-92. PMC: 51324. DOI: 10.1073/pnas.88.7.2788. View

19.

Terman A, Brunk U . Lipofuscin. Int J Biochem Cell Biol. 2004; 36(8):1400-4. DOI: 10.1016/j.biocel.2003.08.009. View

20.

Finkel T, Holbrook N . Oxidants, oxidative stress and the biology of ageing. Nature. 2000; 408(6809):239-47. DOI: 10.1038/35041687. View