Hepatocellular Carcinoma and Vitamin K

Overview

Journal Vitam Horm

Specialties Endocrinology
Nutritional Sciences

Date 2008 Apr 1

PMID 18374204

Citations 6

Authors

Toshihiko Mizuta

Iwata Ozaki

Affiliations

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Abstract

On the basis of reports of the antitumor effects of vitamin K on various cancers, we clinically investigated the suppressive effects of vitamin K2 on tumor recurrence after curative treatment for hepatocellular carcinoma (HCC). Our results showed that vitamin K2 administration significantly suppressed HCC recurrence. Our laboratory findings revealed that the inhibitory effect of vitamin K2 against HCC cell growth was generated by suppressing cyclin D1 expression through inhibition of NF-kappaB activation.

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