Characterization of the Promoter of the Human Gene Encoding the High-affinity IgG Receptor: Transcriptional Induction by Gamma-interferon is Mediated Through Common DNA Response Elements

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1991 Dec 15

PMID 1837149

Citations 54

Authors

R N Pearse

R Feinman

J V Ravetch

Affiliations

Soon will be listed here.

Abstract

Expression of the high-affinity receptor for IgG (Fc gamma RI) is restricted to cells of myeloid lineage and is induced by gamma-interferon (IFN-gamma) but not by IFN-alpha/beta. The organization of the human Fc gamma RI gene has been determined and the DNA elements governing its cell type-restricted transcription and IFN-gamma induction are reported here. A 39-nucleotide sequence (IFN-gamma response region, or GRR) is defined that is both necessary and sufficient for IFN-gamma inducibility. Sequence analysis of the GRR reveals the presence of promoter elements initially defined for the major histocompatibility complex class II genes: i.e., X, H, and gamma-IRE sequences. Comparison of a number of genes whose expression is induced selectively by IFN-gamma indicates that the presence of these elements is a general feature of IFN-gamma-responsive genes. Our studies suggest that the combination of X, H, and gamma-IRE elements is a common motif in the pathway of transcriptional induction by this lymphokine.

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