Interactions of DB75, a Novel Antimalarial Agent, with Other Antimalarial Drugs in Vitro
Overview
Overview
Journal
Antimicrob Agents Chemother
Publisher
American Society for Microbiology
Specialty
Pharmacology
Date
2008 Mar 26
PMID
18362196
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Pafuramidine is a novel orally active antimalarial. To identify a combination partner, we measured the in vitro antimalarial activities of the active metabolite, DB75, with amodiaquine, artemisinin, atovaquone, azithromycin, chloroquine, clindamycin, mefloquine, piperaquine, pyronaridine, tafenoquine, and tetracycline. None of the drugs tested demonstrated antagonistic or synergistic activity in combination with pafuramidine.
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