Porous NiTi for Bone Implants: a Review

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2008 Mar 20

PMID 18348912

Citations 47

Authors

A Bansiddhi

T D Sargeant

S I Stupp

D C Dunand

Affiliations

Soon will be listed here.

Abstract

NiTi foams are unique among biocompatible porous metals because of their high recovery strain (due to the shape-memory or superelastic effects) and their low stiffness facilitating integration with bone structures. To optimize NiTi foams for bone implant applications, two key areas are under active study: synthesis of foams with optimal architectures, microstructure and mechanical properties; and tailoring of biological interactions through modifications of pore surfaces. This article reviews recent research on NiTi foams for bone replacement, focusing on three specific topics: (i) surface modifications designed to create bio-inert porous NiTi surfaces with low Ni release and corrosion, as well as bioactive surfaces to enhance and accelerate biological activity; (ii) in vitro and in vivo biocompatibility studies to confirm the long-term safety of porous NiTi implants; and (iii) biological evaluations for specific applications, such as in intervertebral fusion devices and bone tissue scaffolds. Possible future directions for bio-performance and processing studies are discussed that could lead to optimized porous NiTi implants.

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References

Holton A, Walsh E, Anayiotos A, Pohost G, Venugopalan R . Comparative MRI compatibility of 316 L stainless steel alloy and nickel-titanium alloy stents. J Cardiovasc Magn Reson. 2003; 4(4):423-30. DOI: 10.1081/jcmr-120016381. View

Kim B, Nikolovski J, Bonadio J, Mooney D . Cyclic mechanical strain regulates the development of engineered smooth muscle tissue. Nat Biotechnol. 1999; 17(10):979-83. DOI: 10.1038/13671. View

Ryhanen J, Kallioinen M, Tuukkanen J, Junila J, Niemela E, Sandvik P . In vivo biocompatibility evaluation of nickel-titanium shape memory metal alloy: muscle and perineural tissue responses and encapsule membrane thickness. J Biomed Mater Res. 1998; 41(3):481-8. DOI: 10.1002/(sici)1097-4636(19980905)41:3<481::aid-jbm19>3.0.co;2-l. View

Shabalovskaya S . Surface, corrosion and biocompatibility aspects of Nitinol as an implant material. Biomed Mater Eng. 2002; 12(1):69-109. View

Sumanasinghe R, Bernacki S, Loboa E . Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression. Tissue Eng. 2007; 12(12):3459-65. DOI: 10.1089/ten.2006.12.3459. View

Wu S, Liu X, Chan Y, Ho J, Chung C, Chu P . Nickel release behavior, cytocompatibility, and superelasticity of oxidized porous single-phase NiTi. J Biomed Mater Res A. 2007; 81(4):948-55. DOI: 10.1002/jbm.a.31115. View

Simske S, Sachdeva R . Cranial bone apposition and ingrowth in a porous nickel-titanium implant. J Biomed Mater Res. 1995; 29(4):527-33. DOI: 10.1002/jbm.820290413. View

DE Smet E, Jaecques S, Jansen J, Walboomers F, Vander Sloten J, Naert I . Effect of constant strain rate, composed of varying amplitude and frequency, of early loading on peri-implant bone (re)modelling. J Clin Periodontol. 2007; 34(7):618-24. DOI: 10.1111/j.1600-051X.2007.01082.x. View

Ryan G, Pandit A, Apatsidis D . Fabrication methods of porous metals for use in orthopaedic applications. Biomaterials. 2006; 27(13):2651-70. DOI: 10.1016/j.biomaterials.2005.12.002. View

10.

Wu S, Chu P, Liu X, Chung C, Ho J, Chu C . Surface characteristics, mechanical properties, and cytocompatibility of oxygen plasma-implanted porous nickel titanium shape memory alloy. J Biomed Mater Res A. 2006; 79(1):139-46. DOI: 10.1002/jbm.a.30705. View

11.

Duncan R, Turner C . Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int. 1995; 57(5):344-58. DOI: 10.1007/BF00302070. View

12.

Gu Y, Li H, Tay B, Lim C, Yong M, Khor K . In vitro bioactivity and osteoblast response of porous NiTi synthesized by SHS using nanocrystalline Ni-Ti reaction agent. J Biomed Mater Res A. 2006; 78(2):316-23. DOI: 10.1002/jbm.a.30743. View

13.

Rhalmi S, Odin M, Assad M, Tabrizian M, Rivard C, Yahia L . Hard, soft tissue and in vitro cell response to porous nickel-titanium: a biocompatibility evaluation. Biomed Mater Eng. 1999; 9(3):151-62. View

14.

Greiner C, Oppenheimer S, Dunand D . High strength, low stiffness, porous NiTi with superelastic properties. Acta Biomater. 2006; 1(6):705-16. DOI: 10.1016/j.actbio.2005.07.005. View

15.

Unger R, Sartoris A, Peters K, Motta A, Migliaresi C, Kunkel M . Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials. Biomaterials. 2007; 28(27):3965-76. DOI: 10.1016/j.biomaterials.2007.05.032. View

16.

Thierry B, Merhi Y, Bilodeau L, Trepanier C, Tabrizian M . Nitinol versus stainless steel stents: acute thrombogenicity study in an ex vivo porcine model. Biomaterials. 2002; 23(14):2997-3005. DOI: 10.1016/s0142-9612(02)00030-3. View

17.

Assad M, Chernyshov A, Leroux M, Rivard C . A new porous titanium-nickel alloy: Part 1. Cytotoxicity and genotoxicity evaluation. Biomed Mater Eng. 2002; 12(3):225-37. View

18.

Prymak O, Bogdanski D, Koller M, Esenwein S, Muhr G, Beckmann F . Morphological characterization and in vitro biocompatibility of a porous nickel-titanium alloy. Biomaterials. 2005; 26(29):5801-7. DOI: 10.1016/j.biomaterials.2005.02.029. View

19.

Assad M, Jarzem P, Leroux M, Coillard C, Chernyshov A, Charette S . Porous titanium-nickel for intervertebral fusion in a sheep model: part 1. Histomorphometric and radiological analysis. J Biomed Mater Res B Appl Biomater. 2003; 64(2):107-20. DOI: 10.1002/jbm.b.10530. View

20.

Singh S, Chang E, Gossain A, Mehara B, Galiano R, Jensen J . Cyclic mechanical strain increases production of regulators of bone healing in cultured murine osteoblasts. J Am Coll Surg. 2007; 204(3):426-34. DOI: 10.1016/j.jamcollsurg.2006.11.019. View