Maternal Dietary Intake of Vitamin A and Risk of Orofacial Clefts: a Population-based Case-control Study in Norway

Overview

Journal Am J Epidemiol

Publisher Oxford University Press

Specialty Public Health

Date 2008 Mar 18

PMID 18343877

Citations 22

Authors

Anne Marte W Johansen

Rolv T Lie

Allen J Wilcox

Lene F Andersen

Christian A Drevon

Affiliations

Soon will be listed here.

Abstract

A population-based case-control study was carried out in Norway between 1996 and 2001. The aim was to evaluate the association between maternal intake of vitamin A from diet and supplements and risk of having a baby with an orofacial cleft. Data on maternal dietary intake were available from 535 cases (188 with cleft palate only and 347 with cleft lip with or without cleft palate) and 693 controls. The adjusted odds ratio for isolated cleft palate only was 0.47 (95% confidence interval: 0.24, 0.94) when comparing the fourth and first quartiles of maternal intake of total vitamin A. In contrast, there was no appreciable association of total vitamin A with isolated cleft lip with or without cleft palate. An intake of vitamin A above the 95th percentile was associated with a lower estimated risk of all isolated clefts compared with the 40th-60th percentile (adjusted odds ratio = 0.48, 95% confidence interval: 0.20, 1.14). Maternal intake of vitamin A is associated with reduced risk of cleft palate only, and there is no evidence of increased risk of clefts among women in our study with the highest 5% of vitamin A intake.

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