Innate Recognition of Non-self Nucleic Acids

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2008 Mar 18

PMID 18341708

Citations 17

Authors

Hongbo Chi

Richard A Flavell

Affiliations

Soon will be listed here.

Abstract

The immune system has evolved a plethora of innate receptors that detect microbial DNA and RNA, including Toll-like receptors in the endosomal compartment and RIG-I-like receptors and Nod-like receptors in the cytosol. Here we discuss the recognition of and responses to non-self nucleic acids via these receptors as well as their involvement in autoimmune diseases.

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