Modeling the Cell Division Cycle: Cdc2 and Cyclin Interactions

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1991 Aug 15

PMID 1831270

Citations 127

Authors

J J Tyson

Affiliations

Soon will be listed here.

Abstract

The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.

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References

Cyert M, Kirschner M . Regulation of MPF activity in vitro. Cell. 1988; 53(2):185-95. DOI: 10.1016/0092-8674(88)90380-7. View

Murray A, Kirschner M . Cyclin synthesis drives the early embryonic cell cycle. Nature. 1989; 339(6222):275-80. DOI: 10.1038/339275a0. View

Draetta G, Luca F, Westendorf J, Brizuela L, Ruderman J, Beach D . Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell. 1989; 56(5):829-38. DOI: 10.1016/0092-8674(89)90687-9. View

Hunt T . Embryology. Under arrest in the cell cycle. Nature. 1989; 342(6249):483-4. DOI: 10.1038/342483a0. View

Murray A . Cell biology: the cell cycle as a cdc2 cycle. Nature. 1989; 342(6245):14-5. DOI: 10.1038/342014a0. View

Foe V . Mitotic domains reveal early commitment of cells in Drosophila embryos. Development. 1989; 107(1):1-22. View

Murray A, Kirschner M . Dominoes and clocks: the union of two views of the cell cycle. Science. 1989; 246(4930):614-21. DOI: 10.1126/science.2683077. View

Tyson J . Size control of cell division. J Theor Biol. 1987; 126(4):381-91. DOI: 10.1016/s0022-5193(87)80146-7. View

Moreno S, Nurse P, Russell P . Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast. Nature. 1990; 344(6266):549-52. DOI: 10.1038/344549a0. View

10.

Gautier J, Minshull J, Lohka M, Glotzer M, Hunt T, Maller J . Cyclin is a component of maturation-promoting factor from Xenopus. Cell. 1990; 60(3):487-94. DOI: 10.1016/0092-8674(90)90599-a. View

11.

Lewin B . Driving the cell cycle: M phase kinase, its partners, and substrates. Cell. 1990; 61(5):743-52. DOI: 10.1016/0092-8674(90)90181-d. View

12.

Felix M, Labbe J, Doree M, Hunt T, Karsenti E . Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase. Nature. 1990; 346(6282):379-82. DOI: 10.1038/346379a0. View

13.

Nurse P . Universal control mechanism regulating onset of M-phase. Nature. 1990; 344(6266):503-8. DOI: 10.1038/344503a0. View

14.

Moreno S, Nurse P . Substrates for p34cdc2: in vivo veritas?. Cell. 1990; 61(4):549-51. DOI: 10.1016/0092-8674(90)90463-o. View

15.

Newport J, Kirschner M . Regulation of the cell cycle during early Xenopus development. Cell. 1984; 37(3):731-42. DOI: 10.1016/0092-8674(84)90409-4. View

16.

Newport J, Kirschner M . A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. Cell. 1982; 30(3):675-86. DOI: 10.1016/0092-8674(82)90272-0. View

17.

Evans T, Rosenthal E, Youngblom J, Distel D, Hunt T . Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell. 1983; 33(2):389-96. DOI: 10.1016/0092-8674(83)90420-8. View

18.

Gerhart J, Wu M, Kirschner M . Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs. J Cell Biol. 1984; 98(4):1247-55. PMC: 2113233. DOI: 10.1083/jcb.98.4.1247. View

19.

Hara K, Tydeman P, Kirschner M . A cytoplasmic clock with the same period as the division cycle in Xenopus eggs. Proc Natl Acad Sci U S A. 1980; 77(1):462-6. PMC: 348291. DOI: 10.1073/pnas.77.1.462. View

20.

Bradbury E, Inglis R, Matthews H, LANGAN T . Molecular basis of control of mitotic cell division in eukaryotes. Nature. 1974; 249(457):553-6. DOI: 10.1038/249553a0. View