Pathogen Evasion Strategies for the Major Histocompatibility Complex Class I Assembly Pathway

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2008 Feb 21

PMID 18284468

Citations 27

Authors

Antony N Antoniou

Simon J Powis

Affiliations

Soon will be listed here.

Abstract

Major histocompatibility complex (MHC) class I molecules bind and present short antigenic peptides from endogenously or exogenously derived sources to CD8(+) cytotoxic T lymphocytes (CTL), with recognition of a foreign peptide normally targeting the cell for lysis. It is generally thought that the high level of MHC polymorphism, which is concentrated mostly within the peptide-binding groove, is driven by the 'evolutionary arms race' against pathogens. Many pathogens have developed novel and intriguing mechanisms for evading the continuous sampling of the intracellular and intercellular environments by MHC molecules, none more so than viruses. The characterization of immunoevasion mechanisms has improved our understanding of MHC biology. This review will highlight our current understanding of the MHC class I biosynthetic pathway and how it has been exploited by pathogens, especially viruses, to potentially evade CTL recognition.

Citing Articles

Exploitation of Unconventional CD8 T-Cell Responses Induced by Engineered Cytomegaloviruses for the Development of an HIV-1 Vaccine.

Bruton J, Hanke T Vaccines (Basel). 2025; 13(1).

PMID: 39852851 PMC: 11769474. DOI: 10.3390/vaccines13010072.

The role of the master cancer regulator Pin1 in the development and treatment of cancer.

Stewart R, Sharma S, Wu T, Okuda S, Xie G, Zhou X Front Cell Dev Biol. 2024; 12:1343938.

PMID: 38745861 PMC: 11091292. DOI: 10.3389/fcell.2024.1343938.

Transmission, seroprevalence, and maternal-fetal impact of lymphocytic choriomeningitis virus.

Olivieri N, Othman L, Flannery D, Gordon S Pediatr Res. 2023; 95(2):456-463.

PMID: 37857846 DOI: 10.1038/s41390-023-02859-w.

Intracellular trafficking of HLA-E and its regulation.

He W, Gea-Mallorqui E, Colin-York H, Fritzsche M, Gillespie G, Brackenridge S J Exp Med. 2023; 220(8).

PMID: 37140910 PMC: 10165540. DOI: 10.1084/jem.20221941.

Inhibitory Effects of Infection on MHC-I Expression in Bone Marrow Derived Dendritic Cells.

Rezvan H, Ali S, Hamoon Navard S Iran J Parasitol. 2023; 17(4):562-572.

PMID: 36660416 PMC: 9825691. DOI: 10.18502/ijpa.v17i4.11284.

References

Tortorella D, Story C, Huppa J, Wiertz E, Jones T, Bacik I . Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential. J Cell Biol. 1998; 142(2):365-76. PMC: 2133060. DOI: 10.1083/jcb.142.2.365. View

Schwartz O, Marechal V, Le Gall S, Lemonnier F, Heard J . Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med. 1996; 2(3):338-42. DOI: 10.1038/nm0396-338. View

Hammond C, Braakman I, Helenius A . Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control. Proc Natl Acad Sci U S A. 1994; 91(3):913-7. PMC: 521423. DOI: 10.1073/pnas.91.3.913. View

Zernich D, Purcell A, Macdonald W, Kjer-Nielsen L, Ely L, Laham N . Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. J Exp Med. 2004; 200(1):13-24. PMC: 2213310. DOI: 10.1084/jem.20031680. View

Tu B, Travers K, Weissman J . Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science. 2000; 290(5496):1571-4. DOI: 10.1126/science.290.5496.1571. View

Tomazin R, Hill A, Jugovic P, York I, Van Endert P, Ploegh H . Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP. EMBO J. 1996; 15(13):3256-66. PMC: 451888. View

Williams A, Peh C, Purcell A, McCluskey J, Elliott T . Optimization of the MHC class I peptide cargo is dependent on tapasin. Immunity. 2002; 16(4):509-20. DOI: 10.1016/s1074-7613(02)00304-7. View

Tirosh B, Iwakoshi N, Lilley B, Lee A, Glimcher L, Ploegh H . Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products. J Virol. 2005; 79(5):2768-79. PMC: 548438. DOI: 10.1128/JVI.79.5.2768-2779.2005. View

Kasper M, Roeth J, Williams M, Filzen T, Fleis R, Collins K . HIV-1 Nef disrupts antigen presentation early in the secretory pathway. J Biol Chem. 2005; 280(13):12840-8. DOI: 10.1074/jbc.M413538200. View

10.

Ye Y, Meyer H, Rapoport T . The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature. 2001; 414(6864):652-6. DOI: 10.1038/414652a. View

11.

Zhang Q, Tector M, Salter R . Calnexin recognizes carbohydrate and protein determinants of class I major histocompatibility complex molecules. J Biol Chem. 1995; 270(8):3944-8. DOI: 10.1074/jbc.270.8.3944. View

12.

Bennett E, Bennink J, Yewdell J, Brodsky F . Cutting edge: adenovirus E19 has two mechanisms for affecting class I MHC expression. J Immunol. 1999; 162(9):5049-52. View

13.

Gewurz B, Gaudet R, Tortorella D, Wang E, Ploegh H, Wiley D . Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proc Natl Acad Sci U S A. 2001; 98(12):6794-9. PMC: 34432. DOI: 10.1073/pnas.121172898. View

14.

Barel M, Ressing M, Pizzato N, van Leeuwen D, Le Bouteiller P, Lenfant F . Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation. J Immunol. 2003; 171(12):6757-65. DOI: 10.4049/jimmunol.171.12.6757. View

15.

Cox J, Bennink J, Yewdell J . Retention of adenovirus E19 glycoprotein in the endoplasmic reticulum is essential to its ability to block antigen presentation. J Exp Med. 1991; 174(6):1629-37. PMC: 2119039. DOI: 10.1084/jem.174.6.1629. View

16.

Lee S, Yoon J, Park B, Jun Y, Jin M, Sung H . Structural and functional dissection of human cytomegalovirus US3 in binding major histocompatibility complex class I molecules. J Virol. 2000; 74(23):11262-9. PMC: 113228. DOI: 10.1128/jvi.74.23.11262-11269.2000. View

17.

Leonhardt R, Keusekotten K, Bekpen C, Knittler M . Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex. J Immunol. 2005; 175(8):5104-14. DOI: 10.4049/jimmunol.175.8.5104. View

18.

DEGEN E, Williams D . Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide. J Exp Med. 1992; 175(6):1653-61. PMC: 2119236. DOI: 10.1084/jem.175.6.1653. View

19.

Ahn K, Angulo A, Ghazal P, Peterson P, Yang Y, Fruh K . Human cytomegalovirus inhibits antigen presentation by a sequential multistep process. Proc Natl Acad Sci U S A. 1996; 93(20):10990-5. PMC: 38271. DOI: 10.1073/pnas.93.20.10990. View

20.

Antoniou A, Powis S . Characterization of the ERp57-Tapasin complex by rapid cellular acidification and thiol modification. Antioxid Redox Signal. 2003; 5(4):375-9. DOI: 10.1089/152308603768295104. View