The PE_PGRS Protein Family Acts As an Immunological Decoy to Subvert Host Immune Response

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Jan 11

PMID 35008950

Authors

Tarina Sharma

Anwar Alam

Aquib Ehtram

Anshu Rani

Sonam Grover

Nasreen Z Ehtesham

Seyed E Hasnain

Affiliations

Soon will be listed here.

Abstract

() is a successful pathogen that can reside within the alveolar macrophages of the host and can survive in a latent stage. The pathogen has evolved and developed multiple strategies to resist the host immune responses. escapes from host macrophage through evasion or subversion of immune effector functions. genome codes for PE/PPE/PE_PGRS proteins, which are intrinsically disordered, redundant and antigenic in nature. These proteins perform multiple functions that intensify the virulence competence of majorly by modulating immune responses, thereby affecting immune mediated clearance of the pathogen. The highly repetitive, redundant and antigenic nature of PE/PPE/PE_PGRS proteins provide a critical edge over other proteins in terms of imparting a higher level of virulence and also as a decoy molecule that masks the effect of effector molecules, thereby modulating immuno-surveillance. An understanding of how these proteins subvert the host immunological machinery may add to the current knowledge about virulence and pathogenesis. This can help in redirecting our strategies for tackling infections.

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