Glucose-6-phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2008 Feb 14

PMID 18269318

Citations 83

Authors

Yi-Hsuan Wu

Ching-Ping Tseng

Mei-Ling Cheng

Hung-Yao Ho

Shin-Ru Shih

Daniel Tsun-Yee Chiu

Affiliations

Soon will be listed here.

Abstract

The host cellular environment is a key determinant of pathogen infectivity. Viral gene expression and viral particle production of glucose-6-phosphate dehydrogenase (G6PD)-deficient and G6PD-knockdown cells were much higher than their counterparts when human coronavirus (HCoV) 229E was applied at 0.1 multiplicity of infection. These phenomena were correlated with increased oxidant production. Accordingly, ectopic expression of G6PD in G6PD-deficient cells or addition of antioxidant (such as alpha-lipoic acid) to G6PD-knockdown cells attenuated the increased susceptibility to HCoV 229E infection. All experimental data indicated that oxidative stress in host cells is an important factor in HCoV 229E infectivity.

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