Vaccination Targeting a Surface Sialidase of P. Acnes: Implication for New Treatment of Acne Vulgaris

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2008 Feb 7

PMID 18253498

Citations 29

Authors

Teruaki Nakatsuji

Yu-Tsueng Liu

Cheng-Po Huang

Christos C Zouboulis

Richard L Gallo

Chun-Ming Huang

Affiliations

Soon will be listed here.

Abstract

Background: Acne vulgaris afflicts more than fifty million people in the United State and the severity of this disorder is associated with the immune response to Propionibacterium acnes (P. acnes). Systemic therapies for acne target P. acnes using antibiotics, or target the follicle with retinoids such as isotretinoin. The latter systemic treatment is highly effective but also carries a risk of side effects including immune imbalance, hyperlipidemia, and teratogenicity. Despite substantial research into potential new therapies for this common disease, vaccines against acne vulgaris are not yet available.

Methods And Findings: Here we create an acne vaccine targeting a cell wall-anchored sialidase of P. acnes. The importance of sialidase to disease pathogenesis is shown by treatment of a human sebocyte cell line with recombinant sialidase that increased susceptibility to P. acnes cytotoxicity and adhesion. Mice immunized with sialidase elicit a detectable antibody; the anti-sialidase serum effectively neutralized the cytotoxicity of P. acnes in vitro and P. acnes-induced interleukin-8 (IL-8) production in human sebocytes. Furthermore, the sialidase-immunized mice provided protective immunity against P. acnes in vivo as this treatment blocked an increase in ear thickness and release of pro-inflammatory macrophage inflammatory protein (MIP-2) cytokine.

Conclusions: Results indicated that acne vaccines open novel therapeutic avenues for acne vulgaris and other P. acnes-associated diseases.

Citing Articles

Vaccines in Dermatology-Present and Future: A Review.

Goh E, Chavatte J, Lin R, Ng L, Renia L, Oon H Vaccines (Basel). 2025; 13(2).

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Targeting Inflammation in Acne: Current Treatments and Future Prospects.

Cruz S, Vecerek N, Elbuluk N Am J Clin Dermatol. 2023; 24(5):681-694.

PMID: 37328614 PMC: 10460329. DOI: 10.1007/s40257-023-00789-1.

T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease.

Ouyang K, Oparaugo N, Nelson A, Agak G Front Immunol. 2022; 13:900634.

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Crystal structure of the Propionibacterium acnes surface sialidase, a drug target for P. acnes-associated diseases.

Yu A, Volkers G, Jongkees S, Worrall L, Withers S, Strynadka N Glycobiology. 2021; 32(2):162-170.

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Bruggemann H, Salar-Vidal L, Gollnick H, Lood R Front Microbiol. 2021; 12:673845.

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