Anchoring the Genome

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2008 Jan 30

PMID 18226181

Citations 27

Authors

Diego Ottaviani

Elliott Lever

Petros Takousis

Denise Sheer

Affiliations

Soon will be listed here.

Abstract

Although the principles governing chromosomal architecture are largely unresolved, there is evidence that higher-order chromatin folding is mediated by the anchoring of specific DNA sequences to the nuclear matrix. These genome anchors are also crucial regulators of gene expression and DNA replication, and play a role in pathogenesis.

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