Receptor-mediated Delivery of SiRNAs by Tethered Nucleic Acid Base-paired Interactions

Overview

Journal RNA

Specialty Molecular Biology

Date 2008 Jan 26

PMID 18218703

Citations 10

Authors

Kexiong Zhang

Qiaoqiao Wang

Yanhua Xie

Gil Mor

Emanuela Sega

Philip S Low

Yingqun Huang

Affiliations

Soon will be listed here.

Abstract

We report a new strategy for cell-type-specific delivery of functional siRNAs into cells. The method involves the noncovalent attachment of siRNAs to ligand-conjugated oligodeoxynucleotides via nucleic acid base-paired interactions. The resulting complexes can be directly applied to cells, leading to specific cellular uptake and gene silencing. The method is simple, economical, and can be easily adapted for other cell surface receptors. Here we show the application of this method for the delivery of siRNAs to folate receptor-expressing cells.

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