Genome-wide Demethylation During Neural Differentiation of P19 Embryonal Carcinoma Cells

Overview

Journal J Hum Genet

Specialty Genetics

Date 2008 Jan 18

PMID 18200438

Citations 14

Authors

Izuho Hatada

Sumiyo Morita

Mika Kimura

Takuro Horii

Riu Yamashita

Kenta Nakai

Affiliations

Soon will be listed here.

Abstract

Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.

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