Carbamate-appended N-alkylsulfonamides As Inhibitors of Gamma-secretase

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2008 Jan 8

PMID 18178084

Citations 2

Authors

Carl P Bergstrom

Charles P Sloan

Wai-Yu Lau

David W Smith

Ming Zheng

Steven B Hansel

Craig T Polson

Jason A Corsa

Donna M Barten

Kevin M Felsenstein

Susan B Roberts

Affiliations

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Abstract

The synthesis and gamma-secretase inhibition data for a series of carbamate-appended N-alkylsulfonamides are described. Carbamate 54 was found to significantly reduce brain Abeta in transgenic mice. 54 was also found to possess markedly improved brain levels in transgenic mice compared to previously disclosed 1 and 2.

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