GATA-6 is a Novel Transcriptional Repressor of the Human Tenascin-C Gene Expression in Fibroblasts

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2008 Jan 8

PMID 18177748

Citations 13

Authors

Angela Ghatnekar

Maria Trojanowska

Affiliations

Soon will be listed here.

Abstract

In this study we show that GATA-6 is a novel repressor of TN-C gene expression. We demonstrated that overexpression of GATA-6 in fibroblasts inhibited basal levels, as well as markedly decreased IL-4- and TGF-beta-induced TN-C mRNA and protein levels. A GATA-6 response element was mapped to position -467 to -460 of the TN-C promoter. In addition, we showed that GATA-6 binds this site both in vitro and in vivo.

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