Tenascin-C: Form Versus Function

Overview

Journal Cell Adh Migr

Specialty Cell Biology

Date 2014 Dec 9

PMID 25482829

Citations 113

Authors

Sean P Giblin

Kim S Midwood

Affiliations

Soon will be listed here.

Abstract

Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and effects mediated by, different forms of this molecule in order to fully understand tenascin-C biology. We focus on both post transcriptional and post translational events such as splicing, glycosylation, assembly into a 3D matrix and proteolytic cleavage, highlighting how these modifications are key to defining tenascin-C function.

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