Wegener's Granulomatosis: the Current View

Overview

Journal Clin Rev Allergy Immunol

Specialty Allergy & Immunology

Date 2008 Jan 4

PMID 18172776

Citations 10

Authors

Frank Moosig

Peter Lamprecht

Wolfgang L Gross

Affiliations

Soon will be listed here.

Abstract

In the last few years, substantial progress has been achieved in elucidating the pathogenesis of Wegener's granulomatosis. Several genetic risk factors have been described. The structure of the granuloma and its possible function as ectopic lymphoid tissue have been defined. Furthermore, the consecutive immunopathological reactions leading to induction of PR3-antineutrophil cytoplasmic antibodies (ANCA) and the role of ANCA itself is getting clearer. However, the initial events leading to granuloma formation are still widely unknown. Concerning therapy, the significance of the so-called biological agents (TNF-alpha-blockers, Rituximab) still has to be defined.

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