In Vivo Imaging and Evaluation of Different Biomatrices for Improvement of Stem Cell Survival

Overview

Journal J Tissue Eng Regen Med

Specialties Anatomy & Histology
Biotechnology

Date 2008 Jan 1

PMID 18163533

Citations 19

Authors

Feng Cao

Amir H Sadrzadeh Rafie

Oscar J Abilez

Haichang Wang

Jennifer T Blundo

Beth Pruitt

Christopher Zarins

Joseph C Wu

Affiliations

Soon will be listed here.

Abstract

Therapeutic effects from injection of stem cells are often hampered by acute donor cell death as well as migration away from damaged areas. This is likely due to the fact that injected cells do not have the physical and biochemical cues for ordered engrafment. Here we evaluate 3 common biomatrices (Matrigel, Collagen I, Purmatrix) that has the potential of providing suitable scaffolds needed to enhance stem cell survival. The longitudinal fate of transplanted stem cells was monitored by reporter imaging techniques.

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