Bioelectricity is a Universal Multifaced Signaling Cue in Living Organisms

Overview

Journal Mol Biol Cell

Date 2025 Jan 28

PMID 39873662

Authors

Guangjun Zhang

Michael Levin

Affiliations

Soon will be listed here.

Abstract

The cellular electrical signals of living organisms were discovered more than a century ago and have been extensively investigated in the neuromuscular system. Neuronal depolarization and hyperpolarization are essential for our neuromuscular physiological and pathological functions. Bioelectricity is being recognized as an ancient, intrinsic, fundamental property of all living cells, and it is not limited to the neuromuscular system. Instead, emerging evidence supports a view of bioelectricity as an instructional signaling cue for fundamental cellular physiology, embryonic development, regeneration, and human diseases, including cancers. Here, we highlight the current understanding of bioelectricity and share our views on the challenges and perspectives.

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