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Palladium-catalyzed Direct C-h Arylation of N-iminopyridinium Ylides: Application to the Synthesis of (+/-)-anabasine

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Journal J Am Chem Soc
Specialty Chemistry
Date 2007 Dec 11
PMID 18067305
Citations 19
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Abstract

Palladium-catalyzed direct C-H arylation of N-iminopyridinium ylides provides a powerful and versatile method for the synthesis of functionalized piperidines in good yields. Chemoselective functionalization of the pyridinium ring in the presence of a pyridine substituent is possible as exemplified by the expedient synthesis of anabasine in 61% overall yield over three steps.

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