Unique Functions of the Type II Interleukin 4 Receptor Identified in Mice Lacking the Interleukin 13 Receptor Alpha1 Chain

Overview

Journal Nat Immunol

Date 2007 Dec 11

PMID 18066066

Citations 111

Authors

Thirumalai R Ramalingam

John T Pesce

Faruk Sheikh

Allen W Cheever

Margaret M Mentink-Kane

Mark S Wilson

Sean Stevens

David M Valenzuela

Andrew J Murphy

George D Yancopoulos

Joseph F Urban Jr

Raymond P Donnelly

Thomas A Wynn

Affiliations

Soon will be listed here.

Abstract

The interleukin 4 receptor (IL-4R) is a central mediator of T helper type 2 (T(H)2)-mediated disease and associates with either the common gamma-chain to form the type I IL-4R or with the IL-13R alpha1 chain (IL-13Ralpha1) to form the type II IL-4R. Here we used Il13ra1-/- mice to characterize the distinct functions of type I and type II IL-4 receptors in vivo. In contrast to Il4ra-/- mice, which have weak T(H)2 responses, Il13ra1-/- mice had exacerbated T(H)2 responses. Il13ra1-/- mice showed much less mortality after infection with Schistosoma mansoni and much more susceptibility to Nippostrongylus brasiliensis. IL-13Ralpha1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion but not for fibroblast or alternative macrophage activation. Thus, type I and II IL-4 receptors exert distinct effects on immune responses.

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